madman
Super Moderator
Testosterone May Hold Therapeutic Promise for the Treatment of Ischemic Stroke in Aging: A Closer Look at Laboratory Findings
Fereshteh Farajdokht, Mehdi Farhoudi, Alireza Majdi, Masumeh Zamanlu, Saeed Sadigh-Eteghad, Shabnam Vahedi, Javad Mahmoudi*
Abstract
Male sex is more prone to cerebrovascular disorders, yet the exact role of androgens in cerebral ischemia remains unclear. Here we reviewed current understanding of testosterone (TES) neuroprotective activity against ischemic stroke and mechanisms underlying these effects in aging. TES may exert a neuroprotective effect in aging through pathways including inhibition of oxidant molecules production, enhancing the enzymatic antioxidant capacity of the brain and modulation of apoptotic cell death. Given this, a better understanding of the neuroprotective roles of TES may propose an effective therapeutic strategy to improve the quality of life and decrease androgen-related cerebrovascular problems in the aging men
Conclusion
Based on above, TES neuroprotection against stroke in aging appears to be mediated by several mechanisms including inhibition of production of oxidant molecules, enhancing the enzymatic antioxidant capacity of the brain, activation of PI3K/AKT pathway and enhancing cell survival, inhibition of pro-apoptotic protein through AR dependent MAPK/ERK pathway, as well as improvement of brain neuronal and BBB integrities. These mechanisms may propose future therapeutic strategies to improve the quality of life and decrease androgen-related health problems in the aging population.
Fereshteh Farajdokht, Mehdi Farhoudi, Alireza Majdi, Masumeh Zamanlu, Saeed Sadigh-Eteghad, Shabnam Vahedi, Javad Mahmoudi*
Abstract
Male sex is more prone to cerebrovascular disorders, yet the exact role of androgens in cerebral ischemia remains unclear. Here we reviewed current understanding of testosterone (TES) neuroprotective activity against ischemic stroke and mechanisms underlying these effects in aging. TES may exert a neuroprotective effect in aging through pathways including inhibition of oxidant molecules production, enhancing the enzymatic antioxidant capacity of the brain and modulation of apoptotic cell death. Given this, a better understanding of the neuroprotective roles of TES may propose an effective therapeutic strategy to improve the quality of life and decrease androgen-related cerebrovascular problems in the aging men
Conclusion
Based on above, TES neuroprotection against stroke in aging appears to be mediated by several mechanisms including inhibition of production of oxidant molecules, enhancing the enzymatic antioxidant capacity of the brain, activation of PI3K/AKT pathway and enhancing cell survival, inhibition of pro-apoptotic protein through AR dependent MAPK/ERK pathway, as well as improvement of brain neuronal and BBB integrities. These mechanisms may propose future therapeutic strategies to improve the quality of life and decrease androgen-related health problems in the aging population.
