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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone fractions in blood?
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<blockquote data-quote="madman" data-source="post: 195920" data-attributes="member: 13851"><p>Forget worrying about %.</p><p></p><p>You need to have your SHBG tested to know where it sits let alone TT/FT using (accurate assays) to know whether your TT/FT levels are healthy.</p><p></p><p>Most healthy young men's SHBG would fall in the 30-35 nmol/L range (commonly used reference range is 10-57 nmol/L).</p><p></p><p>You can also test your albumin to see where it sits although it will not have a significant impact on your FT level unless it was abnormally low (hypoalbuminemia).</p><p></p><p></p><p>Total Testosterone = <u>Albumin-bound T + SHBG bound T + unbound Free Testosterone</u></p><p></p><p>Bioavailable Testosterone = <u>Albumin bound T + unbound Free Testosterone</u></p><p></p><p></p><p>Yes, one can have a normal/high-normal TT and experience low-t symptoms if their FT level is low/lowish due to very high SHBG.</p><p></p><p></p><p>[ATTACH=full]12938[/ATTACH]</p><p><strong>Partitioning of testosterone in the systemic circulation. Circulating testosterone is <u>bound tightly to</u> <u>SHBG</u> (green = high-affinity binding) and <u>weakly to albumin, orosomucoid (ORM), and CBG </u>(blue = low-affinity binding) (<a href="https://www.excelmale.com/forum/javascript%3A;" target="_blank">11</a>). <u>Only 1% to 4% of circulating testosterone is unbound or free</u>. The combination of free and albumin-bound testosterone is also referred to as the “bioavailable testosterone” fraction.</strong></p><p></p><p></p><p></p><p></p><p>If you are experiencing low-t symptoms then the only way to truly know if your testosterone levels are low/lowish is to have your TT/FT tested using accurate assays and it should also include your SHBG as many uninformed doctors would only test TT and do not look at FT let alone SHBG levels.</p></blockquote><p></p>
[QUOTE="madman, post: 195920, member: 13851"] Forget worrying about %. You need to have your SHBG tested to know where it sits let alone TT/FT using (accurate assays) to know whether your TT/FT levels are healthy. Most healthy young men's SHBG would fall in the 30-35 nmol/L range (commonly used reference range is 10-57 nmol/L). You can also test your albumin to see where it sits although it will not have a significant impact on your FT level unless it was abnormally low (hypoalbuminemia). Total Testosterone = [U]Albumin-bound T + SHBG bound T + unbound Free Testosterone[/U] Bioavailable Testosterone = [U]Albumin bound T + unbound Free Testosterone[/U] Yes, one can have a normal/high-normal TT and experience low-t symptoms if their FT level is low/lowish due to very high SHBG. [ATTACH type="full"]12938[/ATTACH] [B]Partitioning of testosterone in the systemic circulation. Circulating testosterone is [U]bound tightly to[/U] [U]SHBG[/U] (green = high-affinity binding) and [U]weakly to albumin, orosomucoid (ORM), and CBG [/U](blue = low-affinity binding) ([URL='https://www.excelmale.com/forum/javascript%3A;']11[/URL]). [U]Only 1% to 4% of circulating testosterone is unbound or free[/U]. The combination of free and albumin-bound testosterone is also referred to as the “bioavailable testosterone” fraction.[/B] If you are experiencing low-t symptoms then the only way to truly know if your testosterone levels are low/lowish is to have your TT/FT tested using accurate assays and it should also include your SHBG as many uninformed doctors would only test TT and do not look at FT let alone SHBG levels. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone fractions in blood?
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