Gene Devine
Super Moderator
Testosterone esters are made up with the testosterone molecule and a carbon chain attached to it. This carbon chain controls what is known as “partition co-efficient”, which simply means how soluble the drug will be once it enters the bloodstream.
Depending upon the particular length of the carbon chain for the testosterone ester is what will determine the duration of how long the drug is cleaved (meaning released) into the bloodstream.
In our blood stream there are essentially two enzymes that cleave (or release) the testosterone molecule from the carbon chain. The enzyme called Esterase is mainly responsible for the synthesis of releasing the testosterone off the ester molecule. The Hydrolysate enzyme (a water based enzyme) also helps in the final cleavage process as well. It should be noted that all of this happens in serum not within tissue.
Testosterone propionate is a three carbon chain ester so it is cleaved at a faster rate in the bloodstream by an enzyme known as Esterease.
Testosterone enanthate, on the other hand, is an eight carbon chain ester so it is cleaved at a much longer rate in the bloodstream by the Esterease enzyme and thus a slower release into the bloodstream.
It is these ester carbon chains that defines the drugs half life (solubility) when injected into the blood stream.
Testosterone is testosterone and works the same on androgen receptors when released in the bloodstream; its the ester that is different and brings the variable to the equation.
So, it's the timing of the injection, the dosage administered and the ester compound type itself that determines how much and when is testosterone is released into the bloodstream to increase serum levels.
Once these enzymes releases the testosterone molecule from the ester molecule the testosterone in now bio available (active) for use by androgen receptors, SHBG, Albumin and so on.
Depending upon the particular length of the carbon chain for the testosterone ester is what will determine the duration of how long the drug is cleaved (meaning released) into the bloodstream.
In our blood stream there are essentially two enzymes that cleave (or release) the testosterone molecule from the carbon chain. The enzyme called Esterase is mainly responsible for the synthesis of releasing the testosterone off the ester molecule. The Hydrolysate enzyme (a water based enzyme) also helps in the final cleavage process as well. It should be noted that all of this happens in serum not within tissue.
Testosterone propionate is a three carbon chain ester so it is cleaved at a faster rate in the bloodstream by an enzyme known as Esterease.
Testosterone enanthate, on the other hand, is an eight carbon chain ester so it is cleaved at a much longer rate in the bloodstream by the Esterease enzyme and thus a slower release into the bloodstream.
It is these ester carbon chains that defines the drugs half life (solubility) when injected into the blood stream.
Testosterone is testosterone and works the same on androgen receptors when released in the bloodstream; its the ester that is different and brings the variable to the equation.
So, it's the timing of the injection, the dosage administered and the ester compound type itself that determines how much and when is testosterone is released into the bloodstream to increase serum levels.
Once these enzymes releases the testosterone molecule from the ester molecule the testosterone in now bio available (active) for use by androgen receptors, SHBG, Albumin and so on.
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