madman
Super Moderator
Conclusions
OPIAD is a common AE of opioid treatment in men with CNCP. The presence of OPIAD can negatively affect pain relief and impair sexual function, mood and overall quality of life. However, it is important to recognize that testosterone levels in men progressively decrease as a function of age and comorbidities, which are common in patients with CNCP. Therefore, physicians should consider measuring testosterone levels in all men, before prescribing opioid treatment, and selecting opioids with a lower MOP affinity. In symptomatic patients with OPIAD, if opioid discontinuation is unlikely, TTh may be initiated; however, this decision should be discussed with the patient, emphasizing that, although there is some evidence to support positive shortterm outcomes, the long-term effect of TTh in men with OPIAD is unknown.
OPIAD is a common AE of opioid treatment in men with CNCP. The presence of OPIAD can negatively affect pain relief and impair sexual function, mood and overall quality of life. However, it is important to recognize that testosterone levels in men progressively decrease as a function of age and comorbidities, which are common in patients with CNCP. Therefore, physicians should consider measuring testosterone levels in all men, before prescribing opioid treatment, and selecting opioids with a lower MOP affinity. In symptomatic patients with OPIAD, if opioid discontinuation is unlikely, TTh may be initiated; however, this decision should be discussed with the patient, emphasizing that, although there is some evidence to support positive shortterm outcomes, the long-term effect of TTh in men with OPIAD is unknown.
