Testosterone Decreases Leptin Levels in Dieting Men

Jinzang

Member
A secondary analysis of a previous study reported the result.

Men in the cohort were randomly assigned either 56 weeks of 1,000 mg intramuscular testosterone undecanoate therapy (Reandron, Bayer; n = 49; cases) or a matching placebo (n = 51; controls); 82 men completed the study. The study was conducted between April 2013 and November 2015. For the secondary analysis, primary outcomes were between-group differences during follow-up in levels of leptin, adiponectin, ghrelin, glucagon-like peptide-1, gastric inhibitory polypeptide, peptide PYY, pancreatic polypeptide and amylin.

At 56 weeks, men assigned testosterone therapy had reduced leptin levels vs. controls. Researchers noted that the between-group changes in leptin were dependent on baseline fat mass. There were no significant between-group differences for other hormones at 56 weeks, according to the researchers.

The original news report.

I have to comment that 1000 mg of testosterone a week is a huge dose, how did they ever get approval for a study like that?
 
A secondary analysis of a previous study reported the result.

Men in the cohort were randomly assigned either 56 weeks of 1,000 mg intramuscular testosterone undecanoate therapy (Reandron, Bayer; n = 49; cases) or a matching placebo (n = 51; controls); 82 men completed the study. The study was conducted between April 2013 and November 2015. For the secondary analysis, primary outcomes were between-group differences during follow-up in levels of leptin, adiponectin, ghrelin, glucagon-like peptide-1, gastric inhibitory polypeptide, peptide PYY, pancreatic polypeptide and amylin.

At 56 weeks, men assigned testosterone therapy had reduced leptin levels vs. controls. Researchers noted that the between-group changes in leptin were dependent on baseline fat mass. There were no significant between-group differences for other hormones at 56 weeks, according to the researchers.

The original news report.

I have to comment that 1000 mg of testosterone a week is a huge dose, how did they ever get approval for a study like that?

It would not be 1000mg/weekly if they are using testosterone undecanoate which 750-1000mg is usually given for the first injection than the same dose 4 weeks later and every 10 weeks there after at the same dose. 1000mg/week would be overkill................can anyone say lipids fckd off the charts not to mention side effects from the extreme aromatization to estradiol ( unless on a heavy dose of AIs ).

The only people that would dare injecting 1 gram/week of testosterone would usually be amateur/professional bodybuilders. If it were an average gym rat you either have piss poor genetics or should give up lifting!
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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