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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone Cypionate vs Enanthate Ester break down
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<blockquote data-quote="FunkOdyssey" data-source="post: 267301" data-attributes="member: 44064"><p>Are you accounting for the effect of SC vs IM injection with these half-life claims of 5 days for cypionate and 10 days for Xyosted? How much of Xyosted's longer half life can be attributed to SC injection?</p><p></p><p>If the difference really comes down to lack of excipients, I would expect to see similiar results with Hikma Testosterone Enanthate for example with only 0.5% chlorobutanol as preservative. That compares favorably to common formulations of cypionate and enanthate that contain relatively huge amounts of benzyl benzoate (typically 10-20% by volume). Benzyl benzoate increases drug solubility and absorption rate while chlorobutanol acts only as a preservative.</p><p></p><p>As an aside, benzyl alcohol and benzyl benzoate (which breaks down into benzyl alcohol) are associated with some nasty reactions, from anaphylaxis to something called "gasping syndrome", according to Pfizer in their Testosterone Cypionate documentation:</p><p></p><p></p><p>IMO it is too pharmacologically active a substance to include as a large proportion of testosterone formulations and I imagine it is involved in some percentage of negative reactions attributed to TRT.</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 267301, member: 44064"] Are you accounting for the effect of SC vs IM injection with these half-life claims of 5 days for cypionate and 10 days for Xyosted? How much of Xyosted's longer half life can be attributed to SC injection? If the difference really comes down to lack of excipients, I would expect to see similiar results with Hikma Testosterone Enanthate for example with only 0.5% chlorobutanol as preservative. That compares favorably to common formulations of cypionate and enanthate that contain relatively huge amounts of benzyl benzoate (typically 10-20% by volume). Benzyl benzoate increases drug solubility and absorption rate while chlorobutanol acts only as a preservative. As an aside, benzyl alcohol and benzyl benzoate (which breaks down into benzyl alcohol) are associated with some nasty reactions, from anaphylaxis to something called "gasping syndrome", according to Pfizer in their Testosterone Cypionate documentation: IMO it is too pharmacologically active a substance to include as a large proportion of testosterone formulations and I imagine it is involved in some percentage of negative reactions attributed to TRT. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone Cypionate vs Enanthate Ester break down
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