ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone Cypionate vs Enanthate Ester break down
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 265737" data-attributes="member: 13851"><p>Look over the PKs (pharmacokinetics) they are basically interchangeable other than the fact that some may have a bad reaction to the ester, excipients, or carrier oil used but this is not common.</p><p></p><p></p><p><em><strong>*The purpose of the ester is to control the release rate of the steroid from the oily depot and it is cleaved as soon as it hits the bloodstream releasing free testosterone.</strong></em></p><h4><em><strong>TU/TC/TE/TP (oily depot)----->ester cleaved (ECF)----->FREE TESTOSTERONE (blood)</strong></em></h4><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/combining-cream-and-injection.25696/page-2#post-241765[/URL]</p><p></p><h4><strong>Injectable Testosterone</strong></h4><p><em><strong>The most widely used testosterone formulation for many decades has been an intramuscular injection of testosterone esters (<a href="https://www.ncbi.nlm.nih.gov/books/NBK279000/figure/andro-phys-pharm-abs.F5/?report=objectonly" target="_blank">figure 5</a>), formed by 17β-esterification of testosterone with fatty acids of various aliphatic and/or aromatic chain lengths, injected in a vegetable oil vehicle (<a href="https://www.ncbi.nlm.nih.gov/books/NBK279000/#" target="_blank">653</a>). <u>This depot product relies on retarded release of the testosterone ester from the oil vehicle injection depot because esters undergo rapid hydrolysis by ubiquitous esterases to liberate free testosterone into circulation</u>. <u>The pharmacokinetics and pharmacodynamics of androgen esters are therefore primarily determined by ester side-chain length, the volume of the oil vehicle, and the site of injection via hydrophobic physicochemical partitioning of the androgen ester between the hydrophobic oil vehicle and the aqueous extracellular fluid</u> (<a href="https://www.ncbi.nlm.nih.gov/books/NBK279000/#" target="_blank">654</a>).</strong></em></p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/testosterone-and-hcg-dosing-schedule.25662/#post-228735[/URL]</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/testosterone-enanthate-and-testosterone-cypionate-half-lives-data.23467/#post-201453[/URL]</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/consider-starting-trt.23196/#post-198912[/URL]</p></blockquote><p></p>
[QUOTE="madman, post: 265737, member: 13851"] Look over the PKs (pharmacokinetics) they are basically interchangeable other than the fact that some may have a bad reaction to the ester, excipients, or carrier oil used but this is not common. [I][B]*The purpose of the ester is to control the release rate of the steroid from the oily depot and it is cleaved as soon as it hits the bloodstream releasing free testosterone.[/B][/I] [HEADING=3][I][B]TU/TC/TE/TP (oily depot)----->ester cleaved (ECF)----->FREE TESTOSTERONE (blood)[/B][/I][/HEADING] [URL unfurl="true"]https://www.excelmale.com/forum/threads/combining-cream-and-injection.25696/page-2#post-241765[/URL] [HEADING=3][B]Injectable Testosterone[/B][/HEADING] [I][B]The most widely used testosterone formulation for many decades has been an intramuscular injection of testosterone esters ([URL='https://www.ncbi.nlm.nih.gov/books/NBK279000/figure/andro-phys-pharm-abs.F5/?report=objectonly']figure 5[/URL]), formed by 17β-esterification of testosterone with fatty acids of various aliphatic and/or aromatic chain lengths, injected in a vegetable oil vehicle ([URL='https://www.ncbi.nlm.nih.gov/books/NBK279000/#']653[/URL]). [U]This depot product relies on retarded release of the testosterone ester from the oil vehicle injection depot because esters undergo rapid hydrolysis by ubiquitous esterases to liberate free testosterone into circulation[/U]. [U]The pharmacokinetics and pharmacodynamics of androgen esters are therefore primarily determined by ester side-chain length, the volume of the oil vehicle, and the site of injection via hydrophobic physicochemical partitioning of the androgen ester between the hydrophobic oil vehicle and the aqueous extracellular fluid[/U] ([URL='https://www.ncbi.nlm.nih.gov/books/NBK279000/#']654[/URL]).[/B][/I] [URL unfurl="true"]https://www.excelmale.com/forum/threads/testosterone-and-hcg-dosing-schedule.25662/#post-228735[/URL] [URL unfurl="true"]https://www.excelmale.com/forum/threads/testosterone-enanthate-and-testosterone-cypionate-half-lives-data.23467/#post-201453[/URL] [URL unfurl="true"]https://www.excelmale.com/forum/threads/consider-starting-trt.23196/#post-198912[/URL] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone Cypionate vs Enanthate Ester break down
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top