Testosterone & Cancer Patients: Hope in Fighting Body-Wasting

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Cachexia - A loss of body mass that's common to cancer patients. Almost 20% of cancer-related deaths are attributed to this syndrome which is marked by a rapid and/or severe loss of fat and skeletal muscle. A recent study in the Journal of Cachexia, Sarcopenia, and Muscle shows that testosterone therapy is effective at combatting cachexia and improving the quality of life for patients. This is important because, to date, there are no established therapies these challenges faced by cancer patients.

  • During a five year, National Cancer Institute funded study, patients with squamous cell carcinoma were treated with standard care chemotherapy and/or radiation in addition to seven weeks of testosterone therapy or placebo.
  • Patients receiving testosterone maintained total body mass and increased lean body mass by 3.2%.

"A Randomized Trial of Adjunct Testosterone for Cancer‐Related Muscle Loss in Men and Women," Journal of Cachexia, Sarcopenia, and Muscle, 2018 June 9, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989774/
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

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Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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