A two-year prospective analyses within the Netherlands Study on Depression in Older persons (NESDO) cohort study. The 469 participants comprised 350 patients with Major Depressive Disorder (MDD )and 119 non-depressed participants in the comparison group; mean age 70.5 ± 7.3 years, 166 (35.4%) were men. MDD was assessed by the Composite International Diagnostic Interview (CIDI). Baseline plasma total testosterone and sex hormone binding globulin (SHBG) were assessed to calculate free testosterone. The Inventory of Depressive Symptomatology (IDS) was assessed every 6 months. Testosterone levels were lower in men with MDD compared to healthy men after adjustment for confounders, such as body mass index. No significant associations were found in women.
The full abstract.
The full abstract.
