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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testicular cancer: low T and the metabolic syndrome
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<blockquote data-quote="madman" data-source="post: 170563" data-attributes="member: 13851"><p><strong><span style="color: rgb(184, 49, 47)">Cure rates for stage 1 testicular cancer are reaching 100%.</span></strong> <span style="color: rgb(44, 130, 201)"><strong>However, long-term treatment-related side effects pose their own health risks.</strong></span> <span style="color: rgb(44, 130, 201)"><strong>Regular follow up and monitoring are important for early detection and timely treatment of conditions such as</strong> </span><span style="color: rgb(184, 49, 47)"><strong>testosterone deficiency and metabolic syndrome. </strong></span></p><p></p><p></p><p></p><p></p><p><span style="color: rgb(0, 0, 0)"><strong>Testosterone deficiency following testicular cancer</strong></span></p><p></p><p><span style="color: rgb(0, 0, 0)"><strong>Possible mechanisms for TD following TC </strong></span></p><p></p><p><span style="color: rgb(0, 0, 0)">A low testosterone level may be present when TC is diagnosed, or it may follow treatment for the disease. </span></p><p></p><p><span style="color: rgb(0, 0, 0)"><strong>Causes of TD in the presence of TC include:</strong></span></p><p></p><p><span style="color: rgb(0, 0, 0)"><strong>• </strong></span><span style="color: rgb(184, 49, 47)"><strong>Cancer-related damage to the testicular cells that are responsible for the production of testosterone; </strong></span></p><p><span style="color: rgb(0, 0, 0)"><strong>• </strong></span><span style="color: rgb(184, 49, 47)"><strong>Orchidectomy; </strong></span></p><p><span style="color: rgb(0, 0, 0)"><strong>• </strong></span><span style="color: rgb(184, 49, 47)"><strong>Chemotherapy/RT-related damage to the remaining testicular tissue; </strong></span></p><p><span style="color: rgb(0, 0, 0)"><strong>• </strong></span><span style="color: rgb(184, 49, 47)"><strong>Hormonal abnormalities resulting from cancer-related stress.</strong></span></p><p></p><p></p><p></p><p><span style="color: rgb(0, 0, 0)"><strong>MetS following TC </strong></span></p><p></p><p>Possible mechanisms for MetS following</p><p></p><p><strong>TC While previous research has linked low testosterone levels with a higher fat mass, BMI and abdominal fat distribution in TC survivors, the Platinum study found that TC survivors had smaller waist circumferences in comparison to controls.</strong></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">The aetiology of cancer treatment related MetS appears to differ from that in the general population, where excess calorie intake and a sedentary lifestyle are the primary causes. Cancer treatment-related MetS is multifactorial and differs between individual patients depending on their cancer diagnosis and treatment. TD and chemotherapy are thought to be the main contributors.</span></strong></p><p></p><p></p><p></p><p></p><p><strong>Conclusion </strong></p><p></p><p><span style="color: rgb(184, 49, 47)"><strong>TC survivors may be at risk of various long-term treatment-related adverse effects, including TD and MetS, which can compromise health and wellbeing.</strong></span><span style="color: rgb(44, 130, 201)"><strong> TC commonly affects younger men, and with survival rates increasing, these men may suffer the effects of such chronic conditions over an extended length of time.</strong> </span><strong><span style="color: rgb(44, 130, 201)"><span style="color: rgb(44, 130, 201)">Primary care practitioners need to be alert to the risks following TC and employ careful, regular follow-up in patients who have received treatment for this disease. </span></span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 170563, member: 13851"] [B][COLOR=rgb(184, 49, 47)]Cure rates for stage 1 testicular cancer are reaching 100%.[/COLOR][/B] [COLOR=rgb(44, 130, 201)][B]However, long-term treatment-related side effects pose their own health risks.[/B][/COLOR] [COLOR=rgb(44, 130, 201)][B]Regular follow up and monitoring are important for early detection and timely treatment of conditions such as[/B] [/COLOR][COLOR=rgb(184, 49, 47)][B]testosterone deficiency and metabolic syndrome. [/B][/COLOR] [COLOR=rgb(0, 0, 0)][B]Testosterone deficiency following testicular cancer[/B][/COLOR] [COLOR=rgb(0, 0, 0)][B]Possible mechanisms for TD following TC [/B][/COLOR] [COLOR=rgb(0, 0, 0)]A low testosterone level may be present when TC is diagnosed, or it may follow treatment for the disease. [/COLOR] [COLOR=rgb(0, 0, 0)][B]Causes of TD in the presence of TC include:[/B][/COLOR] [COLOR=rgb(0, 0, 0)][B]• [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]Cancer-related damage to the testicular cells that are responsible for the production of testosterone; [/B][/COLOR] [COLOR=rgb(0, 0, 0)][B]• [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]Orchidectomy; [/B][/COLOR] [COLOR=rgb(0, 0, 0)][B]• [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]Chemotherapy/RT-related damage to the remaining testicular tissue; [/B][/COLOR] [COLOR=rgb(0, 0, 0)][B]• [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]Hormonal abnormalities resulting from cancer-related stress.[/B][/COLOR] [COLOR=rgb(0, 0, 0)][B]MetS following TC [/B][/COLOR] Possible mechanisms for MetS following [B]TC While previous research has linked low testosterone levels with a higher fat mass, BMI and abdominal fat distribution in TC survivors, the Platinum study found that TC survivors had smaller waist circumferences in comparison to controls.[/B] [B][COLOR=rgb(184, 49, 47)]The aetiology of cancer treatment related MetS appears to differ from that in the general population, where excess calorie intake and a sedentary lifestyle are the primary causes. Cancer treatment-related MetS is multifactorial and differs between individual patients depending on their cancer diagnosis and treatment. TD and chemotherapy are thought to be the main contributors.[/COLOR][/B] [B]Conclusion [/B] [COLOR=rgb(184, 49, 47)][B]TC survivors may be at risk of various long-term treatment-related adverse effects, including TD and MetS, which can compromise health and wellbeing.[/B][/COLOR][COLOR=rgb(44, 130, 201)][B] TC commonly affects younger men, and with survival rates increasing, these men may suffer the effects of such chronic conditions over an extended length of time.[/B] [/COLOR][B][COLOR=rgb(44, 130, 201)][COLOR=rgb(44, 130, 201)]Primary care practitioners need to be alert to the risks following TC and employ careful, regular follow-up in patients who have received treatment for this disease. [/COLOR][/COLOR][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testicular cancer: low T and the metabolic syndrome
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