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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
T Propionate protocol
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<blockquote data-quote="tareload" data-source="post: 240626"><p>DHEA upstream of T...</p><p></p><p>[ATTACH=full]27581[/ATTACH]</p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442716/bin/nihms-1599455-f0001.jpg[/URL]</p><p></p><p></p><p><em>Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S), highlighted in orange, together are the most abundant steroids in human circulation. DHEA-S may be converted to DHEA by the action of steroid sulfatase (STS), generating more of this essential sex steroid precursor. These adrenal steroids are derived from cholesterol, which is converted to pregnenolone by cholesterol side-chain cleavage enzyme (CYP11A1). Pregnenolone is subsequently metabolized to 17α-OH-pregnenolone and DHEA by 17α-hydroxylase/17,20-lyase (CYP17A1) in a stepwise reaction. 3β-hydroxysteroid dehydrogenase isotype 1 (3βHSD1) is necessary for the rate-limiting step in the peripheral conversion of DHEA to androstenedione, a reaction that gates the flux of metabolites downstream into sex steroid synthesis pathways. Potent androgens, including testosterone and dihydrotestosterone, may be generated via the action of 17β-hydroxysteroid dehydrogenase (17βHSD) and 5α-reductase (SRD5A). In tissues expressing aromatase, testosterone may be further metabolized to estradiol, a potent estrogen, as shown in pink. While this figure highlights the key enzymatic steps required for the generation of sex steroids, it is important to note that conversion of pregnenolone and 17-OH-pregnenolone to progesterone metabolites primarily occurs in the adrenal gland via the action of 3β-hydroxysteroid dehydrogenase isotype 2 (3βHSD2). The minor physiologic role 3βHSD1 plays in these reactions is indicated by the decreased thickness of the arrows reflecting this enzymatic activity. Not shown is conversion from androstenedione by aromatase to estrone.</em></p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442716/[/URL]</p><p></p><p>Is your argument that serum levels of fT would push back on conversion of DHEA to andro and then T?</p><p></p><p>[ATTACH=full]27582[/ATTACH]</p><p></p><p></p><p>See here:</p><p></p><p></p><p>[URL unfurl="true"]https://academic.oup.com/jcem/article/85/9/3208/2660568[/URL]</p><p>[ATTACH=full]27580[/ATTACH]</p><p>Note that DHEA to androstenedione conversion is irreversible.</p></blockquote><p></p>
[QUOTE="tareload, post: 240626"] DHEA upstream of T... [ATTACH type="full" alt="1671207127955.png"]27581[/ATTACH] [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442716/bin/nihms-1599455-f0001.jpg[/URL] [I]Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S), highlighted in orange, together are the most abundant steroids in human circulation. DHEA-S may be converted to DHEA by the action of steroid sulfatase (STS), generating more of this essential sex steroid precursor. These adrenal steroids are derived from cholesterol, which is converted to pregnenolone by cholesterol side-chain cleavage enzyme (CYP11A1). Pregnenolone is subsequently metabolized to 17α-OH-pregnenolone and DHEA by 17α-hydroxylase/17,20-lyase (CYP17A1) in a stepwise reaction. 3β-hydroxysteroid dehydrogenase isotype 1 (3βHSD1) is necessary for the rate-limiting step in the peripheral conversion of DHEA to androstenedione, a reaction that gates the flux of metabolites downstream into sex steroid synthesis pathways. Potent androgens, including testosterone and dihydrotestosterone, may be generated via the action of 17β-hydroxysteroid dehydrogenase (17βHSD) and 5α-reductase (SRD5A). In tissues expressing aromatase, testosterone may be further metabolized to estradiol, a potent estrogen, as shown in pink. While this figure highlights the key enzymatic steps required for the generation of sex steroids, it is important to note that conversion of pregnenolone and 17-OH-pregnenolone to progesterone metabolites primarily occurs in the adrenal gland via the action of 3β-hydroxysteroid dehydrogenase isotype 2 (3βHSD2). The minor physiologic role 3βHSD1 plays in these reactions is indicated by the decreased thickness of the arrows reflecting this enzymatic activity. Not shown is conversion from androstenedione by aromatase to estrone.[/I] [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442716/[/URL] Is your argument that serum levels of fT would push back on conversion of DHEA to andro and then T? [ATTACH type="full"]27582[/ATTACH] See here: [URL unfurl="true"]https://academic.oup.com/jcem/article/85/9/3208/2660568[/URL] [ATTACH type="full" alt="1671207032097.png"]27580[/ATTACH] Note that DHEA to androstenedione conversion is irreversible. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
T Propionate protocol
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