Switched to less frequent injections..now low e2

[Tylurnt]

Was doing 30mg EOD subq and just felt awful. Trough results
TT 598 ng/DL
FT direct 30.3 (high)
E2 47 (high) Roche method
SHBG 9.6

I switched to 40mg e3 days IM and tested my peak 24hrs after injection 6 weeks in
TT 725
FT direct 27.9
E2 21
SHBG 10.5
HCT 52.1 (high)
Hemo 17.9 (high)

Currently waiting trough results for this protocol...only result i have back so far is TT at 621.

Have no energy or motivation and just kinda a flat anhedonia feeling, Sweaty arm pits while feeling cold... cold intolerance that comes and goes, BO smells stronger etc. Is this low e2? On previous protocol i didnt feel as flat or low motivation but had higher anxiety... still struggled with energy and motivation a good bit on the subq protocol though.

Obvious solution would be to raise dose to raise e2 but cant do that if my H&H. Been struggling to dial in for 10+ months on TRT. What do you guys think? Kinda strange less frequent dosage lowered my e2 so much

 

[Cataceous]

That estradiol isn't overly low, and furthermore, it's likely that estradiol lags testosterone by some time, perhaps a day or two. So it's possible that a day later your estradiol is significantly higher even as testosterone is declining. The lack of energy and motivation sounds like what I experienced while on 100 mg TC/week. Realistically this is an overdose for most men, considering average healthy natural production corresponds to 60-70 mg TC/week. You have other indications that the dose is too high for you: crushed SHBG and high HCT. It took me years to overcome the more-is-better thinking surrounding testosterone. If you haven't already, read some anecdotes from others who also learned the hard way:

Answering some questions, new to forum. Much appreciated! - ExcelMale Forum. TRT, Hormones, Peptides, Men’s Health

Hi, if anyone can help me out that would be great and much appreciated! I’ve been seeing a Dr. for about five years regarding my T levels and have been on the following regiment, I’m 39 yr old male. - 1x 1ml syringe of Testosterone Cypionate out of a (5ml) 200 mg/ml vial every Wednesday (once a...

www.excelmale.com

It seems as though you've explored the upper end of TRT dosing. Maybe it's time to give the lower end a try? Alternatively, you mentioned being on troches originally. You could try going back to those, but at much lower doses. You're looking to absorb around 1.0-1.5 mg two or three times a day. In other words, you want to get Natesto-like results, with short-lived, mid-to-upper-level physiological peaks in serum testosterone, and low troughs that allow your HPTA to start functioning again.

One other thought: You mentioned having a total testosterone of 320 ng/dL before starting TRT. Do you happen to have an SHBG measurement from back then? If you're a guy with naturally low SHBG then it's possible you didn't even need TRT. For example, if your SHBG was also 10 nMol/L originally then your Vermeulen calculated free testosterone would have been over 10 ng/dL, which makes hypogonadism seem less likely. What were your symptoms back then?