Supressing one pituitary hormone affect other pituitary hormones or not?

pepous

New Member
Hello,

i would like to ask experienced members about yours experiences. Does supressing of one pituitary hormone (LH, FSH, ACTH, TSH) results in decline of other pituitary hormone production?

I mean if one start TRT for example. Does that affect production of TSH or ACTH in long term? Is entire pituitary supressed or just LH and FSH decline to zero levels?

What are you experiences?

Thank you very much.
 
If you start a TRT protocol you will suppress HPTA which will essentially shut down the production of LH and FSH hormones vie the negative feedback loop.

This is totally normal and expected.

To make up for the suppression of LH/FSH it is advisable to take HCG which is an LH analog to supplement the lose.

The HCG forum has all the information you need to learn.
 
No, the pituitary is very intricate. Suppressing one hormone should not affect the others as they are managed by completely different stimulating hormones secreted by the hypothalamus. Within the anterior pituitary itself, where the stimulating hormones are received, interactions are specific to the pituitary hormone being synthesized. Also, the actual negative feedback itself is regulated by the specific glandular hormones created from the released pituitary hormone, therefore each hormone pathway has its own regulatory system independent from the others.
 
OK thank you. I am asking due to many says that they needed to increase their thyroids meds after starting TRT. So doing research why and how common it is.

Thank :)
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
4
Guests online
294
Total visitors
298

Latest posts

Back
Top