Supplemental estradiol?

MIP1950

Active Member
I know there are some men on here whose E2 crashed and they're trying to increase their estradiol with tablets. Nelson, I recall, was using estradiol tablets at one time. Dr. Neal Rouzier will prescribe if a patient's lipids are still elevated on T or no weight loss or erectile function. Their E2 becomes quite elevated, supposedly without negative effects. The other side are the few men on here pushing their E2 to <5 and experiencing great mood and sexual improvements. o

Going for labs today. My current protocol; 100 mg Test E, IM E5D. Been on it for 5 weeks. My sex drive/libido is strong, but poor to mediocre erectile function. Always comes up between 9 and 10 at night. Can't go to a lab at that hour to assess what's going on, though I could order a ZRT salivary test. My point is that I feel there's a missing piece and it MIGHT be estradiol; either pushing it down or supplementing to greatly increase it.
 
I would not waste my time with the E2 path. I would increase my nitric oxide.


 
I would not waste my time with the E2 path. I would increase my nitric oxide.


Thank you, Nelson. Problem for me is that using that stack or just L-Citrulline will make me hypomanic; irritable, agitated, as well as negatively impacting my sleep. If I eat a lot of watermelon, which I love, I end up with similar problems.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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