Reply to thread

I have  tried all different combinations a.m. and p.m.

 Different body parts,  splitting dosages, etc.    your numbers are the highest naturally in the a.m. and  reduce towards the night.  It is like recharging a battery when it is low.  Also when you apply in the morning you're going to work the clothing  is rubbing against therefore reducing the  effectiveness of the cream.  For these reasons alone that's why this works for me  and others .