ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
How to Use This Forum and Introductions
Introductions
subcutaneous testosterone cypionate injection sore nodule
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Vince" data-source="post: 15240" data-attributes="member: 843"><p><img src="https://www.excelmale.com/xperience/progress/green.png" class="bbImage" alt="" data-url="https://www.excelmale.com/xperience/progress/green.png" style="" /></p><p>I thought this answer from Dr. Saya of defy Medical was good <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p><p></p><p></p><p> The fact that subq injections do not seem to raise E2 levels more than IM injections (as you originally feared, Dr Crisler), is likely due to the fact that the ester (be it propionate, cypionate, enanthate) is mostly cleaved from the testosterone by esterase enzymes IN THE BLOODSTREAM. This means the testosterone, while sitting in the subq fatty tissue would still mostly have its ester attached. Thus, all of the aromatase sitting around in those adipose cells would be useless for converting the testosterone ester (in other words, the aromatase will convert testosterone (no ester) to estradiol (no ester), but will not convert testosterone cypionate to estradiol cypionate). </p><p></p><p>Once the testosterone ester is absorbed into the blood and the ester is cleaved off to release testosterone itself, then all is fair game whether it came from an IM source OR a subq source - ie: it may circulate and return to the adipose cells to then be converted to E, but this, in effect, removes the location of injection as a significant variable for affecting E levels. Since ester cleavage occurs primarily in the blood, the actual site of injection should have almost no DIRECT impact on E conversion, but may have an INDIRECT impact by way of differing pharmacodynamics of serum T levels in IM vs subq injections.</p><p></p><p>Dr Saya</p></blockquote><p></p>
[QUOTE="Vince, post: 15240, member: 843"] [IMG]https://www.excelmale.com/xperience/progress/green.png[/IMG] I thought this answer from Dr. Saya of defy Medical was good :) The fact that subq injections do not seem to raise E2 levels more than IM injections (as you originally feared, Dr Crisler), is likely due to the fact that the ester (be it propionate, cypionate, enanthate) is mostly cleaved from the testosterone by esterase enzymes IN THE BLOODSTREAM. This means the testosterone, while sitting in the subq fatty tissue would still mostly have its ester attached. Thus, all of the aromatase sitting around in those adipose cells would be useless for converting the testosterone ester (in other words, the aromatase will convert testosterone (no ester) to estradiol (no ester), but will not convert testosterone cypionate to estradiol cypionate). Once the testosterone ester is absorbed into the blood and the ester is cleaved off to release testosterone itself, then all is fair game whether it came from an IM source OR a subq source - ie: it may circulate and return to the adipose cells to then be converted to E, but this, in effect, removes the location of injection as a significant variable for affecting E levels. Since ester cleavage occurs primarily in the blood, the actual site of injection should have almost no DIRECT impact on E conversion, but may have an INDIRECT impact by way of differing pharmacodynamics of serum T levels in IM vs subq injections. Dr Saya [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
X (Twitter)
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
How to Use This Forum and Introductions
Introductions
subcutaneous testosterone cypionate injection sore nodule
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top