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[URL unfurl="true"]https://corporate.dukehealth.org/news/study-solves-testosterones-paradoxical-effects-prostate-cancer[/URL]Probably explains why MTF trans have a 2 fold reduction in PCa but higher PSA when Dx, and why 5ARi reduce PCa risk but increase Gleason score cancers once they are Dx. No androgens present to maintain differentiation so proliferation once initiated goes unchecked, and while a low T environment may slow the process, once far enough advanced, it no longer matters. Interesting study.
[URL unfurl="true"]https://corporate.dukehealth.org/news/study-solves-testosterones-paradoxical-effects-prostate-cancer[/URL]
Probably explains why MTF trans have a 2 fold reduction in PCa but higher PSA when Dx, and why 5ARi reduce PCa risk but increase Gleason score cancers once they are Dx. No androgens present to maintain differentiation so proliferation once initiated goes unchecked, and while a low T environment may slow the process, once far enough advanced, it no longer matters. Interesting study.
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