Study Solves Testosterone’s Paradoxical Effects in Prostate Cancer
DURHAM, N.C. – A treatment paradox has recently come to light in prostate cancer: Blocking testosterone production halts tumor growth in early disease, while elevating the hormone can delay disease progression in patients whose disease has advanced.The inability to understand how different...
Probably explains why MTF trans have a 2 fold reduction in PCa but higher PSA when Dx, and why 5ARi reduce PCa risk but increase Gleason score cancers once they are Dx. No androgens present to maintain differentiation so proliferation once initiated goes unchecked, and while a low T environment may slow the process, once far enough advanced, it no longer matters. Interesting study.
