Study: Anastrozole Sustains Testosterone Levels for Patients on Pellet Therapy

[johndoesmith]

This is an area I am currently researching in pursuit of understanding the vast complexities involving what specifically shuts the HPTA down.

This is an interesting study that I found that basically goes against everything I've seen.



TP = testosterone pellets
TP AZ = testosterone pellets + anastrozole 1mg per day.

 

[Dr Justin Saya MD]

If you could, please post the lab results, improvements, or worsening of symptoms once you start! This is an area I am currently researching in pursuit of understanding the vast complexities involving what specifically shuts the HPTA down. I'd be thrilled to see your labs after starting.

This is an interesting study that I found that basically goes against everything I've seen.

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TP = testosterone pellets
TP AZ = testosterone pellets + anastrozole 1mg per day.

That is indeed intriguing and one I haven't seen.

I will say, however, something is fishy with those estradiol levels still being in the mid-teens with a WHOPPING dosage of 1mg anastrozole daily. I haven't read the actual study, but assume they used the standard assay. I will say I've seen plenty of men with tanked estradiol (<10pg/mL) where the LH/FSH is still suppressed.

 

[johndoesmith]

That is indeed intriguing and one I haven't seen.

I will say, however, something is fishy with those estradiol levels still being in the mid-teens with a WHOPPING dosage of 1mg anastrozole daily. I haven't read the actual study, but assume they used the standard assay. I will say I've seen plenty of men with tanked estradiol (<10pg/mL) where the LH/FSH is still suppressed.

It goes against everything I've seen, too, which admittedly isn't much relative to you.

Maybe you know what this means "Data were analyzed with anova andTukey’s test" regarding assays.

What's fishy about those E2 levels, is their calculation of "T/E2" ratio, 700/18 = 38 not 67 which is what they list for the "TP AZ" group under 0-60 days. Although it could be just because it's a mean.

What's also interesting is that SHBG doesn't change at all, in any of the groups, when exogenous testosterone generally lowers it.

How these men didn't have non existent E2 is beyond me.

 

[johndoesmith]

That is indeed intriguing and one I haven't seen.

I will say, however, something is fishy with those estradiol levels still being in the mid-teens with a WHOPPING dosage of 1mg anastrozole daily. I haven't read the actual study, but assume they used the standard assay. I will say I've seen plenty of men with tanked estradiol (<10pg/mL) where the LH/FSH is still suppressed.

An additional study which further confuses the negative feedback loop's mechanism.