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<blockquote data-quote="bullseye55" data-source="post: 242773" data-attributes="member: 39890"><p>From personal experience I would exercise extreme caution with DMSO and topical testosterone preparations. I originally was using a locally compounded product 10mg/gm applying 5 grams daily. My doctor was not satisfied with the blood levels so he doubled the strength to 20mg/gm, same 5 grams daily. This got me up in the 900s. This was before the lab ranges were dropped. Ten grams of the 10mg/gm was just too much volume, you had it everywhere. I got to reading about DMSO increasing absorption. That's definitely a fact. When I added some DMSO to the palm of my hand along with the 2% cream and rubbed it on in the same manner I got the same result from 1 gram with the DMSO as I did with 5 grams without. Was a huge cost benefit. Several months after starting this I started applying a DHEA/Pregnenolone solution in a base of alcohol/DMSO on the opposite shoulder and would alternate shoulders daily. This was not a problem because DMSO was on both shoulders. What got me into trouble was when the MD decided he wanted to try a commercial product, Testim to see if we could get more consistency. Since I had met my deductible I agreed. What I didn't realize is the DHEA/Pregnenolone solution I was applying to the opposite shoulder and alternating was leaving some residual DMSO in the skin so when the Testim was applied on that shoulder the next day absorption skyrocketed. I never thought about residual activity. Testosterone went up to >1900, spiked my estrogen levels which created a cascade of clotting activity and I landed in the hospital with pulmonary emboli. I am going to expand on the coagulation topic in another post but bottom line is be extremely careful. I would guess only a small percentage of those on trt had a hypercoagulation panel done prior to beginning. That underlying and unknown condition is what made the estrogen spike more dangerous.</p></blockquote><p></p>
[QUOTE="bullseye55, post: 242773, member: 39890"] From personal experience I would exercise extreme caution with DMSO and topical testosterone preparations. I originally was using a locally compounded product 10mg/gm applying 5 grams daily. My doctor was not satisfied with the blood levels so he doubled the strength to 20mg/gm, same 5 grams daily. This got me up in the 900s. This was before the lab ranges were dropped. Ten grams of the 10mg/gm was just too much volume, you had it everywhere. I got to reading about DMSO increasing absorption. That's definitely a fact. When I added some DMSO to the palm of my hand along with the 2% cream and rubbed it on in the same manner I got the same result from 1 gram with the DMSO as I did with 5 grams without. Was a huge cost benefit. Several months after starting this I started applying a DHEA/Pregnenolone solution in a base of alcohol/DMSO on the opposite shoulder and would alternate shoulders daily. This was not a problem because DMSO was on both shoulders. What got me into trouble was when the MD decided he wanted to try a commercial product, Testim to see if we could get more consistency. Since I had met my deductible I agreed. What I didn't realize is the DHEA/Pregnenolone solution I was applying to the opposite shoulder and alternating was leaving some residual DMSO in the skin so when the Testim was applied on that shoulder the next day absorption skyrocketed. I never thought about residual activity. Testosterone went up to >1900, spiked my estrogen levels which created a cascade of clotting activity and I landed in the hospital with pulmonary emboli. I am going to expand on the coagulation topic in another post but bottom line is be extremely careful. I would guess only a small percentage of those on trt had a hypercoagulation panel done prior to beginning. That underlying and unknown condition is what made the estrogen spike more dangerous. [/QUOTE]
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