Good afternoon Gents,
Was wondering if glucosamine, chondroitin, or MSM are even close to nandrolone when it comes to joint pain. Anyone have any experience?
I have read study after study on this same subject and they all seem to say the same thing, "the jury is still out."
"On the basis of the results of recent randomised controlled trials and meta-analyses,
we can conclude that glucosamine sulfate (but not glucosamine hydrochloride) and chondroitin sulfate have small-to-moderate symptomatic efficacy in OA, although this is still debated. With respect to the structure-modifying effect, there is compelling evidence that glucosamine sulfate and chondroitin sulfate may interfere with progression of OA."
Bruyere, O., Reginster, JY. Glucosamine and Chondroitin Sulfate as Therapeutic Agents for Knee and Hip Osteoarthritis.
Drugs Aging 24, 573–580 (2007).
https://doi.org/10.2165/00002512-200724070-00005
That being said, I take 1500mg/d just in case.
Here is one that show a positive effect on slowing the progress of osteoarthritis
Pavelká, K., Gatterová, J., Olejarová, M., Machacek, S., Giacovelli, G., & Rovati, L. C. (2002). Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.
Archives of internal medicine,
162(18), 2113-2123.
Conclusion Long-term treatment with glucosamine sulfate retarded the progression of knee osteoarthritis, possibly determining disease modification.