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Vince, I get that focusing on a number is not ideal, but we need to operate in a range. I have high blood pressure. I have no symptoms and feel the same whether my bp is high or normal but it's still critical to my health to keep my bp in the normal range. Same can be said about Hematocrit. Most don't feel high hematocrit but it's still important to chase a number. So, I believe there has to be a correct answer to the E2 question. There are certainly health issues associated with low or high E2.