Sildenafil 25 mg ODT plus Collagenase Clostridium vs Collagenase Clostridium Alone for the Management of Peyronie’s Disease

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Sildenafil 25 mg ODT þ Collagenase Clostridium hystoliticum vs Collagenase Clostridium hystoliticum Alone for the Management of Peyronie’s Disease: A Matched-Pair Comparison Analysis


CONCLUSION

Although surgical management remains the gold standard for patients with dense plaque calcification or disabling ED, CCH now provides an effective minimally invasive treatment option for men with PD with a palpable plaque and penile curvature deformity of at least 30 at the start of therapy. In this observational, matched-pair comparison between S25 b.i.d. þ CCH vs CCH alone, we demonstrated that combination therapy was superior than CCH alone in terms of penile curvature and ED improvement. Further studies and larger randomized clinical trials are needed to confirm these preliminary observations.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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