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"Lost" effectiveness is too strong of a term. However, I have seen that the testicular response to HCG monotherapy seems to vary over time (both up and down) similar to how the testicular response to endogenous LH seems to vary over time. There is no evidence of testicular "desensitization" at appropriate HCG dosages. Getting older (aging of the testes) will also affect the testicular response (to HCG or LH) over time.