SHBG: who has successfully lowered their levels?

In old men,as cachexia proceeds,fat tissue accumulates.Estradiol peaks and that lowers FT,because SHBG elevates.
Therefore muscle mass can lower SHBG indirectly?
 
SHBG is very difficult to manage serum levels.

One can increase their weekly Testosterone injections to lower SHBG.

For guys who have higher levels of SHBG one weekly injection will help lower SHBG serum levels where guys who have lower SHBG levels twice weekly injections will help increase SHBG.

SHBG is one of those hormones where it finds its own level.

It's not one to really worry about to be totally honest as long as Free and Bio Available Testosterone are in good healthy levels.

Not so sure about where you are coming from. My T was >1500 and SHBG kept rising. As T went up, so did SHBG.
 
This has been my experience too. More T doesn't mean lower SHBG for everyone. I had a doc say that SHBG may be reactive to a sudden increase in outside T so try raising levels slowly. This helped a little in that my free T got ove 1% for the first time, but it didn't maintain... very frustrating. Boron worked for about 2 weeks then stopped. I take vitamin D and magnesium. Right now I'm trying to lower my body fat, but I feel your pain. If you have high SHBG, no one seems to have a good answer.
 
Higher exogenous test will typically increase SHBG due to increasing E levels. Whereas non-aromatizing androgenic steroids like Proviron will lower SHBG. There has been some debate in the past regarding the degree Proviron will inhibit HPTA, not sure what the answer is.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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