madman
Super Moderator
CONCLUSIONS
This study has demonstrated that localized PCa is associated with lower tissue concentrations of TT and higher tissue concentrations of E2 compared with BPH, without any differences regarding DHT tissue concentrations, or TT, DHT, and E2 serum concentrations. Enzymatic activity surrogate markers could reflect a higher activity of the aromatase and the 5-alpha-reductase. These elements might reflect the ability of cancerous prostates to uptake and to transform TT into E2 in the prostatic tissue, while maintaining a “normal” DHT concentration within cancer.
This study has demonstrated that localized PCa is associated with lower tissue concentrations of TT and higher tissue concentrations of E2 compared with BPH, without any differences regarding DHT tissue concentrations, or TT, DHT, and E2 serum concentrations. Enzymatic activity surrogate markers could reflect a higher activity of the aromatase and the 5-alpha-reductase. These elements might reflect the ability of cancerous prostates to uptake and to transform TT into E2 in the prostatic tissue, while maintaining a “normal” DHT concentration within cancer.
