Sex Hormones and Fibromyalgia: The Pain Connection

"In this study Younger measured testosterone, progesterone and estradiol levels as well as cortisol in 8 women with FM for 25 days straight while having them record their pain levels. He found that both progesterone and testosterone were inversely correlated with pain levels; that is, the higher the FM patients’ progesterone and testosterone levels were the lower their pain was."

"In two studies, Hillary White PhD used testosterone gel to successfully reduce pain in fibromyalgia. Her testing revealed that blood testosterone levels of the women entering the study were in the lower half of the normal reference range for their ages. Using the gel normalized, and slightly increased, their testosterone levels to just above the reference range. (The gel does not appear to be FDA-approved.)
A third of the women reported a 50%, or greater, decrease in pain. Forty-two percent were reported to have a 33%, or greater, decrease in pain. Tender point sensitivity was significantly reduced. Libido was significantly increased. The treatment had no effect, though, on headache severity, sleep, anxiety or depression. White also found reductions in fatigue and has proposed that her testosterone gel can help with the intractable kind of fatigue found in chronic fatigue syndrome (ME/CFS).

Source
 

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HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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