CoastWatcher
Moderator
Several findings suggest that testosterone is neuroprotective and that declining levels of testosterone during aging are associated with cognitive and brain pathologies, but little is known about testosterone and brain health in middle-age.
Higher SHBG levels were associated with greater brain white-matter volume. Higher SHBG levels were also associated with lower total and regional gray matter volumes overall. Interestingly, testosterone levels were not related to brain volumes, nor were testosterone or SHBG levels associated with cognitive function.
"Sex hormones and brain volumes in a longitudinal study of middle-aged men in the CARDIA study", Brain Behaviour, 2017 September 20
https://www.ncbi.nlm.nih.gov/pubmed/29075555/
- The study examined 267 men between the "second and fourth decade of life." All underwent brain MRI examinations along with total testosterone, bioavailable testosterone, and SHBG levels also being measured.
- Brain volumes were determined at the ages of 42-56.
Higher SHBG levels were associated with greater brain white-matter volume. Higher SHBG levels were also associated with lower total and regional gray matter volumes overall. Interestingly, testosterone levels were not related to brain volumes, nor were testosterone or SHBG levels associated with cognitive function.
"Sex hormones and brain volumes in a longitudinal study of middle-aged men in the CARDIA study", Brain Behaviour, 2017 September 20
https://www.ncbi.nlm.nih.gov/pubmed/29075555/
