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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
Sermorelin Use - Good Information to help you.
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<blockquote data-quote="BigTex" data-source="post: 217993" data-attributes="member: 43589"><p>I realize that <strong>Sermorelin</strong> is the only peptide approved by the FDA however, it is considered to be one of the weakest of its kind. Here is why - with <strong>Sermorelin</strong> or <strong>GRF 1-29 </strong>the biologically active portion of the 44 amino acid GHRH has a half-life of less than 10 minutes, perhaps as low as 5 minute.</p><p></p><p style="margin-left: 20px">Rapid enzymatic degradation of growth hormone-releasing hormone by plasma in vitro and in vivo to a biologically inactive product cleaved at the NH2 terminus, <em>Frohman LA</em>, J Clin Invest. 1986 78:906–913 and Incorporation of D-Ala2 in Growth Hormone-Releasing Hormone-( l-29)-NH2 Increases the Half-Life and Decreases Metabolic Clearance in Normal Men, <em>STEVEN SOULE</em>, Journal of Clinical Endocrinology and Metabolism 1994 Vol. 79, No. 4.</p> <p style="margin-left: 20px"></p><p>Since they are very easy to acquire on the internet it is a much more effective choice to use <strong>modified GRF(1-29)</strong> or <strong>CJC-1295 w/o the DAC, </strong>which has a half-life at least 30 minutes or so. dosing the 30 minute analog every 3 hours will maximize GH output Dosing the 30 minute analog every 3 hours will maximize GH output especially when combined with one of the <strong>GHRPs</strong>. <strong>GHRH</strong> also has a way of reciprocally reinforcing <strong>GHRPs</strong> action. It does this through four different mechanisms. </p><p></p><p>The first mechanism is the reduction of somatostatin release from the hypothalamus which causes further pulses of GH. </p><p style="margin-left: 40px"></p><p>The second is a reduction of somatostatin influence at the pituitary which inhibits the pituitary gland’s secretion of growth hormone. (see jpg)</p><p></p><p> The third is the increased release of GHRH from the brain. GHRH forms Somatotrope which forms GH.</p><p></p><p> Finally GHRPs act on the same pituitary cells (somatotrophs) as do GHRHs but use a different mechanism to increase cAMP formation which will further cause GH release from somatotroph stores.</p><p></p><p>So you are honestly getting the most bang for the buck using the longer half life of modified GRF (1-29) combined with a GHRP. Using the two, 3 times a day at saturation doses will give you a much larger GH spike in 3 hours that larger doses of rHGH. Sermorelin by itself will increase GH pulses but at a much lower spike. </p><p style="margin-left: 20px"></p> <p style="margin-left: 20px">[ATTACH=full]19842[/ATTACH]</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"></p></blockquote><p></p>
[QUOTE="BigTex, post: 217993, member: 43589"] I realize that [B]Sermorelin[/B] is the only peptide approved by the FDA however, it is considered to be one of the weakest of its kind. Here is why - with [B]Sermorelin[/B] or [B]GRF 1-29 [/B]the biologically active portion of the 44 amino acid GHRH has a half-life of less than 10 minutes, perhaps as low as 5 minute. [INDENT]Rapid enzymatic degradation of growth hormone-releasing hormone by plasma in vitro and in vivo to a biologically inactive product cleaved at the NH2 terminus, [I]Frohman LA[/I], J Clin Invest. 1986 78:906–913 and Incorporation of D-Ala2 in Growth Hormone-Releasing Hormone-( l-29)-NH2 Increases the Half-Life and Decreases Metabolic Clearance in Normal Men, [I]STEVEN SOULE[/I], Journal of Clinical Endocrinology and Metabolism 1994 Vol. 79, No. 4.[/INDENT] [INDENT][/INDENT] Since they are very easy to acquire on the internet it is a much more effective choice to use [B]modified GRF(1-29)[/B] or [B]CJC-1295 w/o the DAC, [/B]which has a[B] [/B]half-life at least 30 minutes or so. dosing the 30 minute analog every 3 hours will maximize GH output Dosing the 30 minute analog every 3 hours will maximize GH output especially when combined with one of the [B]GHRPs[/B]. [B]GHRH[/B] also has a way of reciprocally reinforcing [B]GHRPs[/B] action. It does this through four different mechanisms. The first mechanism is the reduction of somatostatin release from the hypothalamus which causes further pulses of GH. [INDENT=2][/INDENT] The second is a reduction of somatostatin influence at the pituitary which inhibits the pituitary gland’s secretion of growth hormone. (see jpg) The third is the increased release of GHRH from the brain. GHRH forms Somatotrope which forms GH. Finally GHRPs act on the same pituitary cells (somatotrophs) as do GHRHs but use a different mechanism to increase cAMP formation which will further cause GH release from somatotroph stores. So you are honestly getting the most bang for the buck using the longer half life of modified GRF (1-29) combined with a GHRP. Using the two, 3 times a day at saturation doses will give you a much larger GH spike in 3 hours that larger doses of rHGH. Sermorelin by itself will increase GH pulses but at a much lower spike. [INDENT][/INDENT] [INDENT][ATTACH type="full"]19842[/ATTACH][/INDENT] [INDENT][/INDENT] [INDENT][/INDENT] [/QUOTE]
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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
Sermorelin Use - Good Information to help you.
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