Gene Devine
Super Moderator
This was written by Dr Mcclain and Dr Saya
Studies have shown that 1mg of Sermorelin will create maximum stimulation to the pituitary to create a good level of growth hormone within the pituitary. This dose should be used for aprox. 6 months as the anterior pituitary is recrudesced. Therefore, a dose of aprox. 500mcg delivered sc each evening has been shown to provide maximum stimulation to the pituitary releasing optimum endogenous growth hormone. After aprox. 12 months of sermorelin injections, the patient can try reducing injection frequency to 1mg 2-3 times per week to maintain levels.
Again, because the manufacture of endogenous growth hormone by the pituitary is governed by a negative feedback loop, meaning that if the body recognizes that there is an optimum level of endogenous growth hormone being already being produced, then no matter how strongl stimulated by sermorelin, no more endogenous gh will be produced. Note that in truth, the relationship between sermorelin dosing and endogenous growth hormone production is not exactly linear. However, for purposes of discussion and materiality, the aforementioned relationships and limits between sermorelin and endogenous growth hormone are true. So it makes sense to utilize sermorelin to optimize growth hormone levels as determined by the patient’s response itself rather than use exogenous growth hormone through either guesswork or extensive repeated testing.
Using Sermorelin Acetate will promote longevity and lifespan by increasing both production of Human Growth Hormone and increasing pituitary reserves of HGH. Sermorelin does not bypass the pituitary-GH axis therefore allowing control of IGF-1- fluctuating levels as needed to preserve health.
“Growth Hormone Releasing Hormone, called Sermorelin - may provide a superior product for endogenous production of hGH. Unlike exogenous recombinant human growth hormone (rhGH)that causes production of the bioactive hormone IGF-1 from the liver, sermorelin stimulates the patient’s own pituitary gland by binding to specific receptors to increase production and secretion of endogenous hGH.”- Dr . Rand McClain, Sports Medicine Physician LA.
*NOTE: Genuine GHRH combinations and HGH must be prescribed by a physician. Stay away from over-the-counter supplements that claim to boost HGH, known as HGH precursors. The amino acid chains that make up peptides such as Sermorelin or synthetic HGH are very delicate and must be compounded or synthesized under extremely sterile conditions. These peptides cannot survive your digestive enzymes therefore cannot be ingested.
All Sermorelin prescribed by Defy Medical is compounded by a licensed US Pharmacy. All Sermorelin is independently tested by a lab for purity, potency, and endotoxins. Contact us today if you would like to see a copy of the independent lab results.
Sermorelin and decreasing body fat
Lipodystrophy is a medical condition that defines the rapid accumulation of adipose tissue (body fat) usually unevenly distributed in certain areas of the body (legs, hips, stomach, lower back). In basic concept, lipodystrophy is very similar to the increase in body fat experienced as we age, accumulating unevenly in different areas of our body. The Journal of the American Medical Association (JAMA) published a study in 2008 of the effects Sermorelin had on HIV positive men suffering from lipodystrophy.
The study concluded that patients provided 1mg Sermorelin lost adipose (fat) and increased lean muscle, significantly improving total body composition.
Conclusion: GHRH was well tolerated and effectively increased levels of IGF-1 in HIV-infected men with lipodystrophy.
Total and regional body composition improved in response to GHRH, with increased lean mass and reduced truncal and visceral fat. Use of GHRH may potentially be a beneficial treatment strategy for this population. JAMA. 2004;292:210-218 www.jama.com
Dr Rand McClain has observed patients lose significant adipose tissue using Sermorelin. Athletes have long used Sermorelin (GHrh) and similar peptides to decrease body fat and sustain lean muscle. In addition, Sermorelin (just like HGH) plays a significant role in exercise recovery.
Recommend Tri-Amino (1ml qhs) or oral Arginine (3g daily) to potentiate Sermorelin: Defy’s medical team also utilizes injectable amino acids and peptides to help improve results:
“Supplemental parental or enteral Arginine has been shown to stimulate secretion of GH, insulin, and prolactin in humans. Several supplement studies have shown both Arginine and Ornithine to promote GH and insulin secretion with anabolic effects in postoperative patients….because Arginine potentiates the release of pituitary hormones (GH), it can be hypothesized that the beneficial effects of pharmacological doses of the amino acid on protein synthesis, wound healing, and immune function may be mediated via a pituitary messenger such as GH.” Amino Acids and Proteins for the Athlete by Dr Mauro DiPasquale.
Sermorelin 15mg Mixing Instructions
Sermorelin: A better Treatment Approach for Increasing HGH
Introduction to Sermorelin
Studies have shown that 1mg of Sermorelin will create maximum stimulation to the pituitary to create a good level of growth hormone within the pituitary. This dose should be used for aprox. 6 months as the anterior pituitary is recrudesced. Therefore, a dose of aprox. 500mcg delivered sc each evening has been shown to provide maximum stimulation to the pituitary releasing optimum endogenous growth hormone. After aprox. 12 months of sermorelin injections, the patient can try reducing injection frequency to 1mg 2-3 times per week to maintain levels.
Again, because the manufacture of endogenous growth hormone by the pituitary is governed by a negative feedback loop, meaning that if the body recognizes that there is an optimum level of endogenous growth hormone being already being produced, then no matter how strongl stimulated by sermorelin, no more endogenous gh will be produced. Note that in truth, the relationship between sermorelin dosing and endogenous growth hormone production is not exactly linear. However, for purposes of discussion and materiality, the aforementioned relationships and limits between sermorelin and endogenous growth hormone are true. So it makes sense to utilize sermorelin to optimize growth hormone levels as determined by the patient’s response itself rather than use exogenous growth hormone through either guesswork or extensive repeated testing.
Using Sermorelin Acetate will promote longevity and lifespan by increasing both production of Human Growth Hormone and increasing pituitary reserves of HGH. Sermorelin does not bypass the pituitary-GH axis therefore allowing control of IGF-1- fluctuating levels as needed to preserve health.
“Growth Hormone Releasing Hormone, called Sermorelin - may provide a superior product for endogenous production of hGH. Unlike exogenous recombinant human growth hormone (rhGH)that causes production of the bioactive hormone IGF-1 from the liver, sermorelin stimulates the patient’s own pituitary gland by binding to specific receptors to increase production and secretion of endogenous hGH.”- Dr . Rand McClain, Sports Medicine Physician LA.
*NOTE: Genuine GHRH combinations and HGH must be prescribed by a physician. Stay away from over-the-counter supplements that claim to boost HGH, known as HGH precursors. The amino acid chains that make up peptides such as Sermorelin or synthetic HGH are very delicate and must be compounded or synthesized under extremely sterile conditions. These peptides cannot survive your digestive enzymes therefore cannot be ingested.
All Sermorelin prescribed by Defy Medical is compounded by a licensed US Pharmacy. All Sermorelin is independently tested by a lab for purity, potency, and endotoxins. Contact us today if you would like to see a copy of the independent lab results.
Sermorelin and decreasing body fat
Lipodystrophy is a medical condition that defines the rapid accumulation of adipose tissue (body fat) usually unevenly distributed in certain areas of the body (legs, hips, stomach, lower back). In basic concept, lipodystrophy is very similar to the increase in body fat experienced as we age, accumulating unevenly in different areas of our body. The Journal of the American Medical Association (JAMA) published a study in 2008 of the effects Sermorelin had on HIV positive men suffering from lipodystrophy.
The study concluded that patients provided 1mg Sermorelin lost adipose (fat) and increased lean muscle, significantly improving total body composition.
Conclusion: GHRH was well tolerated and effectively increased levels of IGF-1 in HIV-infected men with lipodystrophy.
Total and regional body composition improved in response to GHRH, with increased lean mass and reduced truncal and visceral fat. Use of GHRH may potentially be a beneficial treatment strategy for this population. JAMA. 2004;292:210-218 www.jama.com
Dr Rand McClain has observed patients lose significant adipose tissue using Sermorelin. Athletes have long used Sermorelin (GHrh) and similar peptides to decrease body fat and sustain lean muscle. In addition, Sermorelin (just like HGH) plays a significant role in exercise recovery.
Recommend Tri-Amino (1ml qhs) or oral Arginine (3g daily) to potentiate Sermorelin: Defy’s medical team also utilizes injectable amino acids and peptides to help improve results:
“Supplemental parental or enteral Arginine has been shown to stimulate secretion of GH, insulin, and prolactin in humans. Several supplement studies have shown both Arginine and Ornithine to promote GH and insulin secretion with anabolic effects in postoperative patients….because Arginine potentiates the release of pituitary hormones (GH), it can be hypothesized that the beneficial effects of pharmacological doses of the amino acid on protein synthesis, wound healing, and immune function may be mediated via a pituitary messenger such as GH.” Amino Acids and Proteins for the Athlete by Dr Mauro DiPasquale.
Sermorelin 15mg Mixing Instructions
Sermorelin: A better Treatment Approach for Increasing HGH
Introduction to Sermorelin
