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General Health & Fitness
Health Span Extension Research
Senolytic Drug Advancements For Health Extension
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<blockquote data-quote="FunkOdyssey" data-source="post: 262942" data-attributes="member: 44064"><p>I haven't heard anyone classify rapamycin as a senolytic before. It is often compared and contrasted with senolytics though, and some of the more adventurous are taking rapamycin together with senolytics. Rapamycin is thought to slow aging by inhibiting mTOR and has the effect of preventing cells from becoming senescent, versus the senolytics which kill off senescent cells.</p><p></p><p>More on the distinction here:</p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416555/[/URL]</p><p></p><p>I've tried fisetin as a senolytic before in a 2 gram dose. It caused my joints to flare up, specifically the ones that were bothering me already. They may have felt better than usual afterwards. Or it might all have been placebo. Some have seen more dramatic effects though.</p><p></p><p>I've also used rapamycin before at a dose of 5 mg weekly. That was well tolerated except that it seemed to reduce my already low libido further, which was a deal breaker for me. I'll revisit that in the future when I fix my libido to the point where I can afford to lose a bit.</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 262942, member: 44064"] I haven't heard anyone classify rapamycin as a senolytic before. It is often compared and contrasted with senolytics though, and some of the more adventurous are taking rapamycin together with senolytics. Rapamycin is thought to slow aging by inhibiting mTOR and has the effect of preventing cells from becoming senescent, versus the senolytics which kill off senescent cells. More on the distinction here: [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416555/[/URL] I've tried fisetin as a senolytic before in a 2 gram dose. It caused my joints to flare up, specifically the ones that were bothering me already. They may have felt better than usual afterwards. Or it might all have been placebo. Some have seen more dramatic effects though. I've also used rapamycin before at a dose of 5 mg weekly. That was well tolerated except that it seemed to reduce my already low libido further, which was a deal breaker for me. I'll revisit that in the future when I fix my libido to the point where I can afford to lose a bit. [/QUOTE]
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Senolytic Drug Advancements For Health Extension
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