Scientists report that enzyme that alters testosterone to estrogen has big impact in healthy brain

The demonizing almost always comes as a result of taking way too much anastrazole. Everyone is different and I happen to feel best when my E2 is between 25-30. Good luck.

I’d have to agree. More often than not I think ai’s get a bad rap from men getting their E2 too low, and confusing low E2 symptoms with ai side effects.
 
Shbg: 23.9 (16-55)
Dht: 61 (30-85)
Dhea: 346 ( 138-475)
Last two e2: 45 and 41 on sensitive test.

I was thinking that maybe optimizing DHEA could help you with energy and libido, but yours is pretty decent. There’s still a chance that increasing it could help with those things, but I think trying to get E2 down very slightly to maybe the 20-30 range would be a good route to take. It’s worth a shot, especially considering your SHBG is on the low side.

I was also thinking if your DHT wasn’t that high, increasing your testosterone dose could help increase DHT, which might help libido. But again, yours isn’t too bad. Raising it could have some benefits, but again, trying to adjust E2 might be a better step to take before trying to raise your testosterone dose. Just be very very careful with the ai. To drop your E2 from the low 40’s to the low 20’s is not going to take much at all. But you already know that.
 
One last question, do you take your AI at the same time as your test, or 24h after it?
Lol, I don’t mind the questions at all. I take my AI when I inject my T just to keep things simple. Much less likely to forget a dose and I’m all about keeping things simple. IMHO, guys who overthink every aspect of TRT are always the ones with problems. Again, this is just my opinion.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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