Role of Neurotransmitters & Hormones on Sexual Functioning

I see and definitely believe the effects of the neurotransmitters, and hormones in the two previous slides relative to sexual functioning. What I can't seem to find in searches, exactly for instance is high Prolactin? Is it truly high on the scale used to measure based on a given labs results? Or is it like many other things, an individual patient's level interpreted in conjunction with symptoms, and clinical picture? So, for instance would a patient with issues of penile sensitivity, anorgasmia, or perhaps even difficulty keeping a quality erection with a Prolactin level of 13.5ng/ml on a "normal" scale of 2.0 ng/ml to 18.0 ng/ml be high enough to offer cabergoline? Are there clinically beneficial ways to boost serotonin or oxytocin? Is it fair to suggest, that of all the benefits of HRT, improvement of ED is perhaps the one benefit that requires more time, and patience, and finding the minimal level of both total T and free T as well as time to "heal"?
 
... So, for instance would a patient with issues of penile sensitivity, anorgasmia, or perhaps even difficulty keeping a quality erection with a Prolactin level of 13.5ng/ml on a "normal" scale of 2.0 ng/ml to 18.0 ng/ml be high enough to offer cabergoline?
Dr. Saya says he has at times offered a trial with cabergoline when prolactin is > 10 ng/mL and other likely culprits have been ruled out.

... Is it fair to suggest, that of all the benefits of HRT, improvement of ED is perhaps the one benefit that requires more time, and patience, and finding the minimal level of both total T and free T as well as time to "heal"?
As per the OP I'd say that libido and erectile function can both pretty pretty finicky, and often intertwined. Libido in particular relies on so much more than just the right amount of testosterone.
 
Hi @madman
Do you know how to find this video? Thanks

25:00-51:52
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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