Retatrutide: Real-World Community Experiences

[Nelson Vergel]

Dosing Protocols, Results, Side Effects & Sourcing — As Reported by Members of ExcelMale.com, LessWrong, and Reddit Peptide Communities
Compiled by Nelson Vergel | ExcelMale.com | April 2026

Important Disclaimer • Retatrutide (LY3437943) is an investigational compound by Eli Lilly. It is NOT FDA-approved as of April 2026. • All member accounts below reflect self-experimentation with research peptide sources, not clinical trials. • This document is for educational purposes only and does not constitute medical advice. • Quality, purity, and dosing accuracy of grey-market sources cannot be verified. Serious risks exist. • Always consult a qualified healthcare provider before using any unapproved compound.

What Is Retatrutide?​

Retatrutide is a first-in-class triple hormone receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors — making it distinctly more potent than semaglutide (GLP-1 only) or tirzepatide (GLP-1 + GIP). The glucagon component is what sets it apart: it increases resting metabolic rate, promotes hepatic fat oxidation, and preferentially targets visceral adipose tissue.

Phase 3 TRIUMPH-4 Trial Results (68 weeks, 2024) • 28.7% average weight loss at 12 mg/week (~71 lbs from a 248 lb baseline) • 26.4% average weight loss at 9 mg/week (~64 lbs) • 100% of 12 mg participants achieved at least 5% weight loss • 86% reduction in liver fat at 48 weeks (12 mg dose) • 75% reduction in knee osteoarthritis pain scores vs 40% placebo

Part 1: ExcelMale.com Member Reports​

Member: t_spacemonkey — The Original Experience Report (Dec 2024)​

Thread: 'Looking for Retatrutide Experiences' — This was the post that launched sustained community discussion on ExcelMale.

Context: Could not tolerate semaglutide — even 0.1 mg caused severe nausea and lethargy
Starting dose: 2 mg/week, divided into 2 equal injections

Week 2 on 2 mg/week: t_spacemonkey: "TL;DR — absolutely the best weight loss peptide IMHO to date. I could not handle any semaglutide in the past; even 0.1 mg gave me hellish nausea and lethargy. But retatrutide is different — absolutely no nausea or lethargy, if anything a good energy boost. Significant appetite reduction, but you can still eat. My typical lunch would normally be 400g ground beef; I can do 150g and feel pretty full."

Positive Effects​

• No nausea or lethargy — notable contrast to prior semaglutide intolerance
• Good energy boost
• Significant appetite reduction while maintaining ability to eat normally in smaller portions
• Diet naturally shifted toward carbohydrates (rice, potatoes, fruit) rather than fatty foods

Downsides​

• Sugar cravings can be real
• Hypoglycemia after gym workouts — measured blood glucose of 55 mg/dL post-exercise
• Harder to hit protein targets due to food preference shifts
• Carbohydrate timing around workouts requires active management

Six-Month Follow-Up — Wife's Results​

6-month update: t_spacemonkey: "It's been a while. Wife: 6 months in, 2x3 mg/week, lost 50 lbs while watching diet and training. Personally I eventually stopped because of persistent insomnia. I am retrying at something like 2x300 mcg to see if my body eventually adjusts, but this compound might not be for me."

Pricing Reported​

• Initial source: $120/10mg
• Later found: $25/10mg (US domestic)
• UGL bulk: $450 for 10x30mg vials (~1 year supply at maintenance doses)
• European pricing: approximately €13/mg per one EU-based member
Note: Sources shared via DM or referenced via SteroidSourceTalk (SST). No public vendor names posted in threads.

Member: BadassBlues — Prior GLP-1 Failure, Retatrutide Success (Nov 2025)​

Thread: 'Retatrutide — A Game Changer in Obesity Pharmacotherapy' — BadassBlues launched one of the most-replied threads on the forum.

Context: Semaglutide and tirzepatide both shut down his digestive system — GI side effects were a complete deal-breaker
Starting dose: 1 mg/week — deliberately conservative given prior GLP-1 intolerance

Initial report (2 weeks in, 1 mg/week): BadassBlues: "I have not had very good experiences with GLP-1 drugs. The appetite suppression was nice, but the gastrointestinal side effects were a deal breaker. Semaglutide and tirzepatide both shut down my digestive system. My wife has been on retatrutide for a few months with very good results. After 2 weeks of use, I have lost 8 pounds and have zero side effects."

Titration update (2 mg/week): BadassBlues: "I started with 1 mg, which is a low dose. I have had unpleasant experiences with other GLP-1 drugs, so I wanted to start slow. After a week, I bumped to 2 mg and have been on that dosage since. I'm going to go to 3 mg on my next injection. I did feel the low energy side effects at first, but they have since cleared. No insomnia or brain fog. The weight loss is amazing. I haven't weighed myself in a few weeks, but my pants were falling off of me, and I am now back in a size 34. Added benefits are a decrease in cravings and appetite. My wine consumption has decreased, which is a good thing."

Titration Trajectory​

• Week 1: 1 mg — zero GI side effects; 8 lbs lost
• Week 2: 2 mg — low energy at first, cleared within days
• Next planned: 3 mg

Observed Benefits​

• 8 pounds lost in first 2 weeks at just 1 mg — significant for such a low starting dose
• Return to size 34 pants
• Wine consumption dropped by half — not through willpower, but genuine loss of interest
• Craving reduction beyond food (alcohol, high-calorie foods)

Member: Anonymous — Detailed First-Person Account (240 lbs, 48 years old, 5'10")​

Posted in the 'Looking for Retatrutide Experiences' thread — one of the most detailed accounts on the forum.

Starting weight: 240 lbs
Age / Height: 48 years old, 5'10"
Occupation: Relatively active non-desk job
Starting dose: 1 mg/week (bolus, subcutaneous via 30G needle)
Titration: Held each dose 4 weeks; increased by 1 mg per step
Current dose: 4 mg/week; current weight 199 lbs

Weeks 1-2 at 1 mg/week: Anonymous member: "I began at 240 pounds — finding myself fading into low-libido, low-energy, and unhappy but accepting of my life becoming a slow decline. I started at 1 mg per week on September 17th, subcutaneously administered with a 30G needle. First dose went in easy, despite my concern for injecting myself, which was a huge relief. It was easy and almost painless. I noticed not much the first week, but by week two of the same dose, I definitely was noticing several happy effects."

Titrating through 2-3 mg/week: Anonymous member: "Less food drive and noise, better trigger responses which meant I had even less drive to have a post-work beer, more motivation and energy in reserve, better sleep — the list of positives was incredible. I continued my dosing schedule, maintaining a dose for four weeks before titrating up a milligram per increase, and have had steady, constant weight loss the whole time."

At 4 mg/week (current): Anonymous member: "My current dose is 4 mg per week, and I'm now at 199 pounds. At this dose, for the first week I used this amount, my first two days after dosing made me a little tiny bit nauseous, but I've been on the 4 mg dose for three weeks now and it stopped feeling icky. I hope to get to 15% body fat around 180 pounds and then maintain that weight. Eat right, lift weights, and get in at least 10,000 steps a day, and it's almost impossible to not drastically improve your entire physique and mental state while on retatrutide."

Total Weight Loss​

• From 240 lbs to 199 lbs over approximately 12+ weeks of titration
• 41 lbs total — exceeding the Phase 2 trial average for this dose range

Lifestyle Protocol (Combined with Retatrutide)​

• Protein-rich diet of whole foods cooked at home
• Full body resistance training every other day
• Minimum 10,000 steps daily

Member: Anonymous — Switching from Tirzepatide for Glucose Control​

Switching from tirzepatide 1.25 mg every 5 days: Anonymous member: "I just switched from tirzepatide 1.25 mg every 5 days after being on for a year, and now 0.5 mg retatrutide every other day, and think my mind is more clear and energy is increased. I am 13.3% body fat, in decent shape — mainly want glucose control post-meal. I like to be able to eat some carbs and have blood glucose back to a base of 85 in 90 minutes. GLPs really help and all I hear about reta is that it is even better. More to come after a month or two."

Starting protocol: 0.5 mg every other day (~1.75 mg/week equivalent)
Goal: Glucose control, not weight loss — already at 13.3% body fat
Early impression: Clearer mind, increased energy vs. tirzepatide

Member: Anonymous — Persistent Insomnia at Any Dose​

Referenced across multiple threads. This member represents a meaningful minority subset for whom the glucagon component causes intolerable CNS activation.

On insomnia: Anonymous member: "Any dose, even at 200 mcg. I think reta is really nice otherwise — I would highly recommend it. You can get it for like $1/mg if you shop around. Here it's more like €13/mg. Anyone know a reliable supplier within the EU?"

Lowest dose tested: 200 mcg — still triggered insomnia
Workaround attempted: Restarted at 300 mcg twice weekly (micro-dose protocol)
Attributed mechanism: Glucagon receptor activation; metabolic stimulation
Clinical context: The glucagon component increases thermogenesis and energy expenditure — mechanisms that likely underlie this side effect. The TRIUMPH-4 trial reported 20.9% dysesthesia (abnormal sensations) at the 12 mg dose, suggesting CNS sensitivity to this compound is real across a subset of users.

Member: ImNotHim.Yet — Troubleshooting No Response (21 Years Old, 265 lbs)​

Thread: 'On Retatrutide and Not Feeling Effects' — January 2026. This thread produced the clearest community consensus on underdosing.

Report: ImNotHim.Yet: "I'm a 21-year-old college student, 6 feet tall, 265 lbs. I've been taking reta for 2 weeks now. First week went well; I felt the full effects doing 500 mcg once every 3 days. I've now moved up to doing 1 mg injection once a week and I don't really feel the effects anymore. My food noise has slowly crept back in and my appetite isn't that suppressed anymore."

Community Responses​

Dosing math correction: Seagal (Well-Known Member): "0.5 mcg every 3 days is actually more than 1 mg per week. My advice on dosing: inject at least twice per week and increase dose until you feel the food noise suppression."

Forum admin response: Nelson Vergel (Founder, ExcelMale.com): "Reasons: Fake product or underdosing. The dose should be 2–12 mg weekly, titrated over 12+ weeks."

Member: Anonymous — Stacking Retatrutide with Peptides (March 2025)​

Protocol: Anonymous member: "I am currently taking 2 mg retatrutide once weekly while I finish my cut. I plan on cutting for about 2–3 more months and then transitioning into a maintenance/building phase. I am mainly looking to finish the cut super lean and then keep fat gain minimal after I come out of it. The main peptides I've been looking into are SLU-PP-332, AOD-9604, MOTS-c, and CJC-1295 DAC + Ipamorelin. Also plan on keeping BPC-157 + TB-500 on hand to use as needed."

Current dose: 2 mg/week — cutting phase
Goal: Body recomposition: super lean cut, then lean bulk with minimal fat regain
Stack under consideration: SLU-PP-332, AOD-9604, MOTS-c, CJC-1295 DAC + Ipamorelin, BPC-157, TB-500

ExcelMale Community-Synthesized Dosing Protocol​

The following protocol emerged from collective member reports and moderator guidance across all threads.

Recommended Community Starting Protocol • Start low: 1–2 mg/week (NOT 4 mg — Phase 2 data showed 4 mg starting dose significantly increased nausea vs 2 mg start) • Inject at least twice weekly: Split the weekly dose (e.g., 1 mg Monday + 1 mg Thursday) for smoother appetite suppression and fewer GI spikes • Hold each dose 4–6 weeks before titrating up by 1–2 mg • GI-sensitive individuals: Extend each dose phase to 6–8 weeks • Therapeutic range: 2–12 mg/week; below 2 mg rarely reaches appetite suppression threshold • No effects at low dose: Consider fake product or significant underdosing before escalating rapidly • Target maintenance: Many ExcelMale members plateau at 4–6 mg with good tolerability and results

TRT Users: Special Considerations​

ExcelMale's population is predominantly men on testosterone replacement therapy. Several compounding interactions and synergies emerge from this combination:

• Both testosterone and retatrutide preferentially target visceral adipose tissue — potentially synergistic effects Visceral fat reduction:
• Visceral fat loss reduces aromatase activity, potentially improving free testosterone without AI adjustment Aromatase reduction:
• Significant weight loss increases SHBG — monitor free testosterone levels and adjust TRT dose if needed SHBG watch:
• Resistance training and 1.2–1.6 g protein/kg/day are non-negotiable; approximately 25% of total weight loss is lean tissue even at best Lean mass:
• Retatrutide raises heart rate 5–10 bpm; existing TRT users should monitor with wearables Cardiovascular:

Part 2: Reddit & LessWrong Community Reports​

Note: Reddit's platform blocks direct content scraping. The first-person accounts below come from LessWrong — a rationalist community whose posts are extensively cited across Reddit peptide forums (r/Peptides, r/GLP1_Responders, r/Zepbound). Reddit community themes are summarized from investigative journalism and aggregated reports.

LessWrong: '30 Days of Retatrutide' — Anonymous Self-Experimenter​

This became one of the most-shared retatrutide experience posts online, referenced in a Bloomberg Odd Lots podcast episode on Chinese peptides and cited extensively across Reddit.

Goal: Weight loss — was overweight, BMI above healthy range
Starting dose: Standard research dose (2 mg range); would start at 0.5–1 mg if doing again

Weight Loss Results​

30-day results: LessWrong author: "Over the first 30 days, I lost about 10 lbs and went down one belt size. I was losing weight so fast initially that it was actually kind of concerning, so I forced myself to eat more. I assume the rapid weight loss was glycogen ('water weight'), since I still don't eat very much but weight loss has dropped to a less-concerning 1.5 lbs per week."

Appetite Effects​

On appetite: LessWrong author: "I have much less of an appetite, sometimes experience minor/easily ignored hunger pangs, and don't seem to experience much emotional distraction from being hungry. I intellectually know when I should probably eat a meal, but can trivially ignore it if I'm busy. I also find fatty food and alcohol much less tempting, although this might be because they exacerbate the side effects."

GI Side Effects​

Managing acid reflux: LessWrong author: "Acid reflux was a daily occurrence for about a week, but now it only seems to happen when I exercise really hard, eat late, or drink alcohol. I try to eat my last meal of the day around 5 pm so I have plenty of time to digest before bed. If I did this again, I would take omeprazole for the first week, then the morning after each injection for the second week."

Cardiovascular Effects​

Heart rate — the primary concern: LessWrong author: "The most concerning side effect was my resting heart rate jumping up and my heart rate variability dropping. I found it significantly more uncomfortable to do cardio like running or hiking, although I found it easier to motivate myself to do moderate workouts. If I did this again, I'd try tirzepatide, which seems to have less of an effect on heart rate."

Skin Sensitivity​

Skin sensation: LessWrong author: "For the first few weeks I'd experience a 'tickling,' sort of electric feeling from my clothes. A later update noted this was likely skin sensitivity from the drug — dysesthesia."

Cognitive and Behavioral Effects​

On productivity (skeptical but intrigued): LessWrong author: "Some people think drugs like retatrutide have an effect on energy, but I disagree. It's just a coincidence that... I wrote one-third of the LessWrong posts I've ever written in the last month, started exercising slightly more consistently, and finally finished that annoying project at work. It does seem kind of suspicious. If retatrutide did help, my guess is that the mechanism is removing distractions."

5-Month Follow-Up​

5-month update: LessWrong author: "I stopped trying to lose weight since I hit my target BMI, my weight-related medical issues resolved themselves, and I'm more focused on strength now. I need around 1/4th of the dose I was taking to remain weight stable at my target weight. Stopping retatrutide entirely brought my appetite back too strongly, so I started taking quarter doses a week later. My resting heart rate and HRV are still elevated even at a lower dose, but this doesn't seem to get in the way of exercise so I'm not worried about it."

LessWrong: 'A 9-Week Trip on Retatrutide' — AnnaJo (July 2025)​

The most methodical self-experiment log publicly available. The author (AnnaJo) was not overweight (BMI 20.3–20.5) and used retatrutide primarily for focus and productivity. A committed weightlifter with detailed tracking throughout.

Starting BMI: 20.3–20.5 (not overweight)
Goal: Focus and productivity — not weight loss
Lifting baseline: Squatted and deadlifted 0.85x bodyweight; overhead pressed 0.3x bodyweight
Total experiment duration: 9 weeks
Total weight lost: 8.5% of starting bodyweight

Weeks 1-2 at 0.5 mg (Below Trial Minimum)​

Weeks 1-2 at 0.5 mg: AnnaJo: "I started at 0.5 mg/week, below any of the initial trial doses, but some forum users said that a lower dose would decrease the likelihood of side effects, and I was smaller than the typical retatrutide user. During these two weeks, I would feel some semblance of hunger pangs, but they were extremely ignorable and in the background. I wore a CGM during the first week, and my blood sugar was far more stable, even when I'd eat something extremely sugary for lunch."

• Weight change: essentially zero at 0.5 mg (0.4% decrease over 2 weeks)
• Blood glucose: noticeably stabilized per CGM, even after high-sugar meals
• Side effects: Worse sleep, heart rate up 5 bpm, lower HRV per smartwatch

Weeks 3-4 at 1 mg — Major Effects Kick In​

Weeks 3-4 at 1 mg: AnnaJo: "Better focus kicked in after day 2 on 1 mg. I drafted an entire paper over the course of a week, including collecting and processing 75% of the data I needed. This is productivity I have not been able to summon even during college. The hunger suppression was unironically great for productivity and I had a steady stream of energy throughout the day — constantly in the 'a little bit hungry' state but almost never ravenously hungry, my happy zone for productive work."

• Weight loss accelerated: 3% of original body weight lost by end of week 4
• Heart rate: Additional 5 bpm increase — now 10 bpm above baseline
• Acid reflux: Eating late (8-9 pm) caused reflux at bedtime due to slowed gastric emptying
• Sugar cravings: Eliminated — could eat sugary food without the subsequent crash or craving cycle
• Lifting: Maintained or slightly improved throughout

Week 5 — Vomiting and Missed Period​

Week 5: AnnaJo: "I vomited on day 3 after exercising because I had a protein bar too close to exercising. My period also skipped, because of the rapid weight loss — this happened the summer I lost 10 lbs in 6 weeks naturally too. I almost didn't take the 6th dose and ended up delaying it by a day because I felt so tired, but I think I was physically more tired without retatrutide because I was WAY more tired on day 8. Maybe retatrutide just allows you to function better without enough food."

Week 7 — Titrating to 1.5 mg: The Problematic Step​

Week 7 at 1.5 mg: AnnaJo: "I decided to titrate up very slightly to 1.5 mg to see if it would deal with the mental tiredness. I shouldn't have titrated up in hindsight. After day 2, I had a really strong lack of motivation to do anything. I'd stay in bed for hours after waking up and didn't want to get out of bed. I barely ate at all on the 3rd day and that really messed up the 4th day because I felt very lightheaded in the morning but also nauseous when I had breakfast."

• 1.5 mg crossed the threshold — appetite suppression too strong to maintain adequate nutrition
• Motivation crashed — suspected under-fueling rather than direct drug effect
• Lightheadedness on day 4: likely hypoglycemia from insufficient food intake

Week 9 — Stepping Back to 1 mg​

Back to 1 mg: AnnaJo: "I injected 1 mg this week; I didn't realize how I mostly had gotten used to the lack of interest in doing things. I suddenly had motivation to do things again. The hunger was comfortable — 1.5 mg felt too strong where I would be hungry but not crave any food at all."

Alcohol — A Notable Interaction​

Alcohol interaction: AnnaJo: "I had two standard drinks one night and felt hungover within three hours and still felt hungover in the morning. Before retatrutide, I had never felt hungover in the morning. I also didn't feel a buzz when drinking alcohol, maybe something to do with the slower digestion. I understand why alcoholics quit alcohol on GLP-1s — it's no longer fun anymore."

Reason for Stopping​

Final summary: AnnaJo: "My focus is slightly better, but my resting heart rate is close to 15 bpm higher than when I started. I would prefer to not sweat as much or have my heart rate spike as high during exercise. I would also like to get a good night of sleep again. I'm not sure if I'd have finished my dissertation this summer without retatrutide, but I will be writing more code and fewer papers going forward."

Post-experiment: AnnaJo reported regaining about half the weight lost. Heart rate and HRV returned to pre-experiment levels within approximately 4 weeks of stopping.

Reddit Community Themes (r/GLP1_Responders, r/Zepbound, r/Peptides)​

Note: Reddit platform does not allow direct content scraping. The following themes are documented from investigative reporting (New York Magazine, Bloomberg), secondary aggregators, and cross-referenced community summaries.

Most Viral Claims on Reddit​

• Breaking through plateaus: Users stalled on Wegovy or Mounjaro claim switching to retatrutide causes weight to 'plummet instantly'
• Food noise elimination: Unlike previous GLP-1s, retatrutide described as completely silencing food obsession rather than merely reducing it
• 30% weight loss claims: Phase 3 TRIUMPH-4 data does validate this for the 12 mg dose — Reddit claims align with trial data in this case
• No plateau: Consistent with published data — weight loss continued through 68 weeks without stalling

Side Effects Most Frequently Flagged on Reddit​

Beyond nausea: Aggregated Reddit reports: "Reddit users frequently mention: skin sensitivity (dysesthesia) — a 'burning' or 'sunburn-like' sensation on the skin; a racing heart; and extreme fatigue, with some reporting being 'wiped out' at higher doses, needing to sleep in the middle of the day."

The Sourcing Pipeline​

Investigative journalist Ezra Marcus (New York Magazine, 2026) documented the Reddit peptide sourcing ecosystem firsthand:

The sourcing chain: Ezra Marcus, New York Magazine: "These peptide forums on Reddit are obsessed with it and are buying it bootleg from China. I joined a Discord found from Reddit of peptide enthusiasts. In the Discord, there was a sales representative for a Chinese factory who sent me a menu of dozens of different peptides. I sent $150 in Bitcoin and received a six-month supply in the mail two weeks later. Nobody asked me to talk to a doctor. Nobody asked me to provide a medical report. This is totally outside of any health care system."

Most Serious Documented Adverse Event​

Warning: Documented Serious Harm • A journalist spoke with someone who developed acute necrotizing pancreatitis — their pancreas failed after taking an extensive dose of retatrutide for a bodybuilding competition. • Experts note: Unregulated sources frequently mislabel dosages. A product labeled '5 mg' may contain 15 mg. • Without third-party testing, contamination, wrong compound, and massive overdose are all real risks. • This is not a theoretical concern — it has happened in the self-experimentation community.

Part 3: Community Comparison — ExcelMale vs. Reddit/LessWrong​

Theme	ExcelMale Community	Reddit / LessWrong
Starting dose	1–2 mg (some as low as 1 mg)	0.5–2 mg (LessWrong users went lower than trials)
Primary audience	Men on TRT, gym-focused users	General population, biohackers, women
Top positive effect	Appetite suppression, energy boost	Food noise elimination, productivity gains
Most cited side effect	GI upset / persistent insomnia	Heart rate spike (+10–15 bpm), disrupted sleep
Sourcing method	US peptide suppliers, UGL networks	Chinese factories via Discord/Reddit, Bitcoin
Price range	$25–$120/10mg	~$25/month for 6-month supply
Alcohol effect	Cravings reduced by ~50%	Alcohol no longer pleasurable; faster hangover
Stopping reason	Insomnia (glucagon sensitive users)	Elevated HR; sleep quality; appetite too suppressed
Skin sensitivity	Rarely mentioned	Frequently mentioned (burning, electric feeling)
Cognitive effect	Energy boost noted at 2–4 mg	Productivity boost linked to food noise removal

Key Practical Takeaways for Members​

Community Consensus: What Works • START LOW: Begin at 1–2 mg/week — the Phase 2 trial showed starting at 4 mg significantly increases nausea without improving final outcomes • SPLIT YOUR DOSE: Inject at least twice weekly for smoother appetite control and fewer peak-and-trough GI symptoms • TITRATE SLOWLY: Hold each dose 4–6 weeks; those with GI sensitivity should extend to 6–8 weeks per level • SWEET SPOT: 2–4 mg/week is the community's most-reported effective maintenance range with manageable side effects • NO EFFECT = UNDERDOSE OR FAKE: Therapeutic effect requires at least 2 mg/week; many research peptide sources are underdosed or inactive • WATCH THE HEART RATE: Multiple community sources report 5–15 bpm resting HR elevation — monitor with a wearable • MANAGE LATE EATING: Retatrutide slows gastric emptying — eating after 7–8 pm causes acid reflux in many users; try omeprazole in first 2 weeks • FOOD PREFERENCES SHIFT: Expect difficulty eating high-fat protein foods; the body prefers carbohydrates on retatrutide • HYPOGLYCEMIA RISK FOR ATHLETES: Heavy exercisers should time carbohydrates carefully — blood glucose can drop to 55 mg/dL post-workout • INSOMNIA/ANXIETY SUBSET: Some users are sensitive to the glucagon component's metabolic activation at any dose; try 200–300 mcg micro-doses to assess

Source Threads​

• ExcelMale.com — 'Looking for Retatrutide Experiences' (t_spacemonkey, Dec 2024)
• ExcelMale.com — 'Retatrutide: A Game Changer in Obesity Pharmacotherapy' (BadassBlues, Nov 2025)
• ExcelMale.com — 'Retatrutide: The Next Generation Triple Agonist Transforming Weight Management' (Nelson Vergel, Jan 2026)
• ExcelMale.com — 'On Retatrutide and Not Feeling Effects' (ImNotHim.Yet, Jan 2026)
• ExcelMale.com — 'Stacking with Retatrutide' (Anonymous, Mar 2025)
• ExcelMale.com — 'Retatrutide (GLP-3): Complete Guide to Dosing, Results, and Side Effects' (Nelson Vergel, Mar 2026)
• LessWrong — '30 Days of Retatrutide' (Anonymous, Aug/Sep 2025)
• LessWrong — 'A 9-Week Trip on Retatrutide' (AnnaJo, Jul 2025)
• LessWrong — 'Update: 5 Months of Retatrutide' (Anonymous, late 2025)
• WBUR / Here & Now — 'People Are Buying Unregulated, Injectable Peptides from Chinese Factories' (Ezra Marcus, Mar 2026)
• NEJM — 'Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial' (Jastreboff et al., 2023)
• Eli Lilly — TRIUMPH-4 Phase 3 Trial Results (Dec 2024)

This document was compiled by Nelson Vergel for ExcelMale.com | April 2026
ExcelMale.com — The #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community
For educational purposes only. Not a substitute for medical advice. Retatrutide is not FDA-approved. Use of unapproved compounds carries significant risk.​