I could not deal with no libido while on Sertraline, so I stopped taking it as soon as I got that stressful job behind me. However, that was a year before my testosterone started declining below 500, so from blood tests I saw during the year I took the SSRI, I don't think it lowered my testosterone significantly, because it was around 500 during that year (if I recall correctly). Unfortunately, I never had my testosterone level checked before maybe 7 or 8 years ago, when it was at 780, so I have no idea what my levels were when I was in my 30's and felt "normal". But I am extremely happy with where I am at today. I had arthritis pain in my lower back from 2014 to 2018 and I took Advil once or twice per day for pain. Since getting my T levels up, I don't take Advil anymore and I can lift weights again in the gym with no pain in my lower back or in other joints or tendons. I hope that the Testosterone gel will help you. Keep us posted!