Ratio of Testosterone and Estradiol

Larry B

New Member
I attempted to post this earlier but it isn't appearing so I'm trying again.
I've been on anastrozole for 11 years. I believe since I started, science has evolved and lowering estradiol down into the 25 pg/mL range is no longer desirable as I have been told to do by my doctor all these years. Recently I've read more and more that estradiol should not be that low in men.

I always kept it low for fear of gynecomastia, fat accumulation, ED and libido but now read the opposite may be true. A few years ago I developed terrible tendinitis and now I believe it may have been associated with low estradiol. Is there a testosterone to estradiol ratio for men? Recent research has led me to believe that if one has a high testosterone level their estradiol level can and should be above the high level of normal on the Labcorp and Quest test values. Basically the higher the testosterone level the higher the estradiol level can and should be.

Does anyone know what men with naturally high levels of testosterone have for an estradiol level? I found this ratio calculator but not sure exactly what it means. My total testosterone on my last blood draw was 845 ng/dL and my estradiol was 32.2 pg/mL. It appears those are two different units of measure. Can anyone tell me based on my numbers if my ratio is in a good range? Also, what is considered a good ratio?

 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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