Reply to thread

This is because both androgens and estrogens suppress GnRH production at the hypothalamus. A SERM stops the negative feedback only from the estrogens. In contrast, at the pituitary the negative feedback on gonadotropin production is mainly from estrogens, and a SERM is effective. Therefore, if GnRH is delivered directly then the pituitary can be coaxed to make LH and FSH, even concurrent with TRT, as described here.

I wonder if your side effects from Clomid were mainly due to zuclomiphene? It's a travesty that the FDA did not approve enclomiphene, which would have led to more widespread availability. Having only one legitimate source makes its use a tenuous proposition. Other SERMs may work, but each could have issues. For example, the liver toxicity of tamoxifen.