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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question for some of the knowledgeable guys on the board about HCG
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<blockquote data-quote="Cataceous" data-source="post: 178189" data-attributes="member: 38109"><p>This is because both androgens and estrogens suppress GnRH production at the hypothalamus. A SERM stops the negative feedback only from the estrogens. In contrast, at the pituitary the negative feedback on gonadotropin production is mainly from estrogens, and a SERM is effective. Therefore, if GnRH is delivered directly then the pituitary can be coaxed to make LH and FSH, even concurrent with TRT, as described <a href="https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results.20864/#post-176010" target="_blank">here</a>.</p><p></p><p>I wonder if your side effects from Clomid were mainly due to zuclomiphene? It's a travesty that the FDA did not approve enclomiphene, which would have led to more widespread availability. Having only one legitimate source makes its use a tenuous proposition. Other SERMs may work, but each could have issues. For example, the liver toxicity of tamoxifen.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 178189, member: 38109"] This is because both androgens and estrogens suppress GnRH production at the hypothalamus. A SERM stops the negative feedback only from the estrogens. In contrast, at the pituitary the negative feedback on gonadotropin production is mainly from estrogens, and a SERM is effective. Therefore, if GnRH is delivered directly then the pituitary can be coaxed to make LH and FSH, even concurrent with TRT, as described [URL='https://www.excelmale.com/forum/threads/pituitary-restart-while-on-trt-promising-initial-results.20864/#post-176010']here[/URL]. I wonder if your side effects from Clomid were mainly due to zuclomiphene? It's a travesty that the FDA did not approve enclomiphene, which would have led to more widespread availability. Having only one legitimate source makes its use a tenuous proposition. Other SERMs may work, but each could have issues. For example, the liver toxicity of tamoxifen. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question for some of the knowledgeable guys on the board about HCG
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