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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question for guys on trt long term
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<blockquote data-quote="xqfq" data-source="post: 156468" data-attributes="member: 38167"><p>That's an interesting point I hadn't considered! Trenbolone, which is the most notorious of anabolic steroids for insane libido, apparently binds to the progesterone receptor very strongly. I also notice lots of varicose veins on men who've used anabolic steroids heavily, which I suspect may be due to this progesterone receptor binding as well..or it could just be increased blood demand (or maybe both?)</p><p></p><p>Not to get too technical (!) and (to be honest, off topic) but -- I think it's difficult to draw analogies with anabolic steroids because it's not just a receptor activation causing the effect; the androgen, estrogen and progesterone receptors are <em>nuclear receptors. </em>This means it's possible that each steroid has different effects on downstream gene expression, irrespective of binding affinity. A good analogy to see how this works is DHT versus T. They both bind to the androgen receptor but exert different effects on genes. So I believe it's more than simple binding affinity and ratios when looking at these AAS / SARM effects. It's hard to say where e.g. Trenbolone gets its libido effect because of this -- could it be because it does something similar to DHT (libido?) on the androgen receptor, or because of something having to do with the progesterone receptor? Etc.</p></blockquote><p></p>
[QUOTE="xqfq, post: 156468, member: 38167"] That's an interesting point I hadn't considered! Trenbolone, which is the most notorious of anabolic steroids for insane libido, apparently binds to the progesterone receptor very strongly. I also notice lots of varicose veins on men who've used anabolic steroids heavily, which I suspect may be due to this progesterone receptor binding as well..or it could just be increased blood demand (or maybe both?) Not to get too technical (!) and (to be honest, off topic) but -- I think it's difficult to draw analogies with anabolic steroids because it's not just a receptor activation causing the effect; the androgen, estrogen and progesterone receptors are [I]nuclear receptors. [/I]This means it's possible that each steroid has different effects on downstream gene expression, irrespective of binding affinity. A good analogy to see how this works is DHT versus T. They both bind to the androgen receptor but exert different effects on genes. So I believe it's more than simple binding affinity and ratios when looking at these AAS / SARM effects. It's hard to say where e.g. Trenbolone gets its libido effect because of this -- could it be because it does something similar to DHT (libido?) on the androgen receptor, or because of something having to do with the progesterone receptor? Etc. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question for guys on trt long term
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