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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question for guys on trt long term
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<blockquote data-quote="xqfq" data-source="post: 156449" data-attributes="member: 38167"><p>I'm sorry you're having these problems. I too had extreme anxiety, insomnia and sort of weird joint pain. I was sure I had low E2 and went and got tested..turns out my E2 (LC/MS/MS) was perfectly normal.</p><p></p><p>HCG in high doses gave me immediate relief from these symptoms but was unreliable. I kept digging. I'm not sure of anything really, but I believe that these symptoms were caused by low progesterone.</p><p></p><p>I would recommend measuring your progesterone levels. It's a $30 lab on discounted labs. I am still researching all of the effects of progesterone. I will make a comprehensive post once I've learned more and done more personal research..but I believe it can alleviate many of the negative symptoms guys experience on TRT when their numbers are otherwise "in range."</p><p></p><p>I believe it is due to biases on it being a "female hormone" it has not been adequately investigated in TRT. Progesterone also has a negative reputation due to the synthetic forms having side effects such as increased blood clotting.</p><p></p><p>But natural progesterone does not really have these issues, see e.g. this table on blood lipid impact of synthetic versus natural progesterone:</p><p></p><p>[ATTACH=full]8106[/ATTACH]</p><p></p><p>The bad reputation also comes from its usage as a form of chemical castration in men. But that is just because it suppresses the HPTA, just like estrogen does -- NOT because it actually decreases libido itself in normal male doses. So a guy not on TRT shouldn't really take progesterone regularly because it may suppress the HPTA, but for a guy on TRT it can make a lot of sense if there are symptoms IMO!</p><p></p><p>The fact your symptoms didn't change with dosage also matches with it being a progesterone problem. This is because the HTPA shutdown causes the progesterone reduction.</p></blockquote><p></p>
[QUOTE="xqfq, post: 156449, member: 38167"] I'm sorry you're having these problems. I too had extreme anxiety, insomnia and sort of weird joint pain. I was sure I had low E2 and went and got tested..turns out my E2 (LC/MS/MS) was perfectly normal. HCG in high doses gave me immediate relief from these symptoms but was unreliable. I kept digging. I'm not sure of anything really, but I believe that these symptoms were caused by low progesterone. I would recommend measuring your progesterone levels. It's a $30 lab on discounted labs. I am still researching all of the effects of progesterone. I will make a comprehensive post once I've learned more and done more personal research..but I believe it can alleviate many of the negative symptoms guys experience on TRT when their numbers are otherwise "in range." I believe it is due to biases on it being a "female hormone" it has not been adequately investigated in TRT. Progesterone also has a negative reputation due to the synthetic forms having side effects such as increased blood clotting. But natural progesterone does not really have these issues, see e.g. this table on blood lipid impact of synthetic versus natural progesterone: [ATTACH=full]8106[/ATTACH] The bad reputation also comes from its usage as a form of chemical castration in men. But that is just because it suppresses the HPTA, just like estrogen does -- NOT because it actually decreases libido itself in normal male doses. So a guy not on TRT shouldn't really take progesterone regularly because it may suppress the HPTA, but for a guy on TRT it can make a lot of sense if there are symptoms IMO! The fact your symptoms didn't change with dosage also matches with it being a progesterone problem. This is because the HTPA shutdown causes the progesterone reduction. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question for guys on trt long term
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