Probiotic Improved Mens Fertility LH FSH Testosterone

[Robotics]

Summary
The hypothesis that the assumption of a probiotic associated with a prebiotic (Flortec, Bracco; one sachet contains: Lactobacillus paracasei B21060 5 × 109 cells + arabinogalctan 1243 mg + oligo‐fructosaccharides 700 mg + l‐glutamine 500 mg) could improve the quality and quantity of spermatozoa in idiopathic oligoasthenoteratospermia (iAOT) patients to a larger extent than a control substance (starch) was tested. Forty‐one patients with no chromosomal aberrations were randomized into two groups: 20 received Flortec, one sachet per day for 6 months, whereas 21 received the control substance. The following data were collected: clinical history, scrotal Doppler scans, Y microdeletion, karyotype and cystic fibrosis screens, follicle‐stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T), and prolactin (PRL) levels, and two semen analyses. Both the Flortec and the starch groups underwent two semen analyses and one FSH, LH, T, E2, and PRL measurement in the blood, at the beginning of the study, and after 6 months. The comparisons were carried out using a non‐parametric (Wilcoxon signed rank) test. The side effects were assessed and compared using the chi‐squared test. Group 1 (Flortec) had their sperm count improved: volume of the ejaculate (median from 2.4 to 3.1 mL; p < 0.01), sperm concentration (median: from 15.2 × 106/mL to 28.3 × 106/39 mL; p < 0.01), progressive motility (median: from 16.2 to 42.0%; p < 0.01), and the percentage of typical forms (median: from 7 to 16.3%; p < 0.01); in addition, their FSH, LH, and T levels improved (p < 0.01), while those of E2 and PRL did not. Group 2 (control substance) had no modification in 42 of the parameters studied. There were no side effects in either group. These data showed that Flortec constitutes a safe therapy for improving the volume of the ejaculate and the quality/quantity of spermatozoa in iOAT patients.

Link to full paper below

Full Paper Text

 

[Robotics]

@Nelson Vergel @madman @Systemlord

What do you guys think? mind going through the paper? one thing that stands out to me is how high their T levels were at baseline.

 

[Nelson Vergel]

An interesting small placebo-controlled study. Thanks for sharing.

This is the supplement they used:

Supplement Flortec For Intestinal Balance 10 Sachets



A lot of things can improve sperm quality. The other parameters are a little harder to improve with supplements (ejaculate volume).

Top Supplements That Improve Sperm Quality

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[madman]

@Nelson Vergel @madman @Systemlord

What do you guys think? mind going through the paper? one thing that stands out to me is how high their T levels were at baseline.

Thanks for posting.


Table 1 shows the baseline demographic and clinical characteristics for each group. No significant differences emerged.

Table 2 summarizes the results of each study group, that is,the volume of the ejaculate, sperm concentration, sperm motility, percentage of typical forms, and blood level of FSH, LH, PRL,T, and E2 before and after a 6-month administration of Flortec or starch (Group 2). Volume of the ejaculate, sperm concentration, sperm motility, number of ejaculated spermatozoa, and percentage of typical forms significantly improved in Group 1 patients at 6 months, while in Group 2, these parameters did not improve (see Fig. 1). The levels of FSH, LH, and T increased inGroup 1, while E2 and PRL did not. Group 2 had no hormone significantly improved. Side effects were absent in both groups.


DISCUSSION AND CONCLUSION

These data showed that Flortec is safe for improving the volume of the ejaculate, the sperm concentration, the number of ejaculated spermatozoa, the motility, and the percentage of typical forms when administered to iOAT patients. Furthermore, Flortec administration increased FSH, LH, and T blood levels.


Supplementation with Flortec had a strong effect on the quality/quantity of sperm let alone hormones (TT 729--->865 ng/dL).

We know that gut health contributes greatly to a strong immune system and that prebiotics/probiotics, antioxidants all play a role.

Seems that one of the mechanisms Flortec may have is an impact on free radicals/inflammation.


At present, it is unknown what the mechanism of action of the active drug is; Flortec administration increased blood gonadotropins and T, which stimulate spermatogenesis (Cavallini, 2006; Garollaet al., 2014).

All of these data, associated with the low cost of the active drug and its easy administration, legitimized our intention to carry out this study on a larger scale in order to assess the mechanism of action of Flortec, its efficacy in achieving spontaneous pregnancies, in improving DNA fragmentation, and in improving outcomes of assisted reproduction techniques.