Premature ejaculation is one of the most common sexual health concerns for men, but it’s often surrounded by stigma, embarrassment, and misinformation. In this episode, host Vic Senese, RN, BSN, FAUNA is joined by Jeff Abraham, CEO of Promescent, to break down everything you need to know about PE — from the real causes and persistent myths to proven treatments that actually work.
We’ll cover:
* What premature ejaculation really is and why it happens
* Common myths and misconceptions that make it worse
* Evidence-based strategies and treatment options
* How couples can talk openly about it without shame
* The role of lifestyle, mental health, and communication
* The company’s candidate, KH-001, is derived from a plant long used in traditional South African medicine. The active alkaloid targets the serotonin transporter, acting through the same molecular pathway as selective serotonin reuptake inhibitors (SSRIs) but with distinct pharmacologic advantages. Preclinical and early clinical findings indicate that KH-001 binds selectively and with high potency to the serotonin receptor without affecting other central nervous system targets, suggesting a potentially improved safety profile.
Predict estradiol, DHT, and free testosterone levels based on total testosterone
⚠️ Medical Disclaimer
This tool provides predictions based on statistical models and should NOT replace professional medical advice.
Always consult with your healthcare provider before making any changes to your TRT protocol.
ℹ️ Input Parameters
Normal range: 300-1000 ng/dL
Predicted Hormone Levels
Enter your total testosterone value to see predictions
Results will appear here after calculation
Understanding Your Hormones
Estradiol (E2)
A form of estrogen produced from testosterone. Important for bone health, mood, and libido.
Too high can cause side effects; too low can affect well-being.
DHT
Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth,
prostate health, and masculinization effects.
Free Testosterone
The biologically active form of testosterone not bound to proteins.
Directly available for cellular uptake and biological effects.
Scientific Reference
Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.
