Pregnenolone Supplementation...

jth0524

Member
I just bought a product by Life Extension called Cognitex With Pregnenolone. I added this as an adjunct to my TRT. I have had several concussions/TBI's in my past. I thought it might be a little insurance against future brain disease. It has pregnenolone in it which has been proven to decline in people on TRT. Pregnenolone is thought to be neuroprotective. I am on HCG as well, but was intrigued by this supplement considering my past head trauma. 3 capsules equal 50mg of pregnenolone. I'm thinking of taking maybe one in the morning and one more in the afternoon or evening which would give me just over 30mg of pregnenolone a day. Is this too much? One capsule would be about 17mg of pregnenolone. I guess I'm wondering two things. How much pregnenolone is good to take? Also, does time of day matter? Thanks in advance.
 
Everybody responds differently. What is too much/too little for one guy will be just right for another. The only way to know is to take it for 4-5 weeks and gauge how you feel.
 
Agree with Vince. 10mg should be enough. Do you take DHEA as well? Pregnenolone will increase DHEA levels so if you do take DHEA you might need to reduce the dosage a bit. A blood test for DHEA-S would be ideal in this case.
I started pregnenolone at 25mg a day and later reduced to 10mg a day (along with 10mg of DHEA) and I feel much better. DHEA-S is in the upper normal range.
Look into pure encapsulations products. In my opinion their supplements are one of the best and that is really important specially when it comes down to hormones.
 
Look into pure encapsulations products. In my opinion their supplements are one of the best and that is really important specially when it comes down to hormones.
That's the brand I use, I also believe they're one of the best brands to use for DHEA and Pregnenolone.
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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