Preclinical Study of Leydig Cell Failure Therapies Using Lhcgr Deficient Mouse Model

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Zhenmin Lei, M.D., Ph.D., Professor of Obstetrics & Gynecology and Vice-Chair for Research, Department of Obstetrics, Gynecology & Women's Health at the University of Louisville School of Medicine, presented "Preclinical Study of Leydig Cell Failure Therapies Using Lhcgr Deficient Mouse Model" at Endocrinology Grand Rounds on February 23, 2022.

 

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Advances in stem cell research for the treatment of primary hypogonadism

Abstract In Leydig cell dysfunction, cells respond weakly to stimulation by pituitary luteinizing hormone, and, therefore, produce less testosterone, leading to primary hypogonadism. The most widely used treatment for primary hypogonadism is testosterone replacement therapy (TRT). However, TRT...

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Leydig cell aging: Molecular mechanisms and treatments

Abstract Late-onset hypogonadism, resulting from a deficiency in serum testosterone (T), affects the health and quality of life of millions of aging men. T is synthesized by Leydig cells (LCs) in response to luteinizing hormone (LH). LH binds LC plasma membrane receptors, inducing the formation...

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Leydig stem cells and future therapies for hypogonadism

Leydig stem cells and future therapies for hypogonadism Justin K. Achua, Fabio S. Frech, and Ranjith Ramasamy Purpose of review In this review, we outline the most recent advances in the development of Leydig stem cells (LSCs) and summarize the current and upcoming treatments for...

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Breakthrough in testosterone-producing cells could lead to treatment for ‘low T’

Breakthrough in testosterone-producing cells could lead to treatment for ‘low T’ Low testosterone can affect men’s mood, sex life and health. USC scientists say they’ve hit upon a potential new solution.

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