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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Peak & trough timing on daily subq injections?
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<blockquote data-quote="Cataceous" data-source="post: 160386" data-attributes="member: 38109"><p>I'm going to say that, regarding estradiol, Vince's numbers seem to be out of the ordinary and may not reflect what most guys would see. There's no big spike in testosterone to drive the spike in estradiol. And I suspect that even though it's only ~10% off the others, the first testosterone measurement is inaccurate and should be much closer to the other two, as is pretty much guaranteed with daily injections of a long-lived testosterone ester. This makes it pretty hard to come up with a plausible explanation for the estradiol surge. If this were repeatable it would point to something not previously characterized. Bear in mind that studies of normal men show only about 10-20% diurnal variation in estradiol and very little change in SHBG, meaning free estradiol is relatively static. Estradiol does indeed usually follow testosterone.</p><p></p><p>The sensitive estradiol test, though more accurate when done right, is also prone to very large errors when the technique is not perfect. The non-sensitive test is very reliable and repeatable, but is subject to positive systematic bias due to false recognition of other substances as estradiol. There's no clear winner between the tests, but if you find the bias of the non-sensitive test to be consistent then it will give more reliable results overall if you use it and correct for the bias. It would be interesting to see how well this works with other measurements from Vince now that we've determined that his non-sensitive results should be multiplied by 0.75.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 160386, member: 38109"] I'm going to say that, regarding estradiol, Vince's numbers seem to be out of the ordinary and may not reflect what most guys would see. There's no big spike in testosterone to drive the spike in estradiol. And I suspect that even though it's only ~10% off the others, the first testosterone measurement is inaccurate and should be much closer to the other two, as is pretty much guaranteed with daily injections of a long-lived testosterone ester. This makes it pretty hard to come up with a plausible explanation for the estradiol surge. If this were repeatable it would point to something not previously characterized. Bear in mind that studies of normal men show only about 10-20% diurnal variation in estradiol and very little change in SHBG, meaning free estradiol is relatively static. Estradiol does indeed usually follow testosterone. The sensitive estradiol test, though more accurate when done right, is also prone to very large errors when the technique is not perfect. The non-sensitive test is very reliable and repeatable, but is subject to positive systematic bias due to false recognition of other substances as estradiol. There's no clear winner between the tests, but if you find the bias of the non-sensitive test to be consistent then it will give more reliable results overall if you use it and correct for the bias. It would be interesting to see how well this works with other measurements from Vince now that we've determined that his non-sensitive results should be multiplied by 0.75. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Peak & trough timing on daily subq injections?
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