Peak and Trough variation...

[jth0524]

For those in the know, or who have measured both their peak and trough while on test cypionate, what is the general variation between the peak and trough blood levels on an every 3.5 day injection protocol? I gather that the peak and trough difference will be more evened or smoothed out on an every 3.5 day protocol versus a once a week one. I know that everyone is different and that each individual will vary. But in general, let's say that on trough day the testosterone level was 831. Would the peak be in the 1200 range or closer to 1000? I'm just trying to gain an understanding of generally what everyone's experience has been on what the testosterone range is from lowest to highest on an every 3.5 day protocol. Thanks

 

[ERO]

It varies a lot depending upon one's SHBG levels so it would be difficult to have a useful "rule of thumb." Best way to find out is get one blood test done the day of injection and then another one done the day of your next injection, but BEFORE you inject. Costs you some money, but then you know for sure.

 

[Vince Carter]

I saw with 50mg EOD a 24hr peak of 1475 and a trough in the 800's...I have low SHBG and can go thru T very fast.

 

[Nasdaq]

I also have wondered about the variation between peak and trough days. I was looking for information on the topic, such as a mean variation between the two points, but could not find anything.

 

[CoastWatcher]

I also have wondered about the variation between peak and trough days. I was looking for information on the topic, such as a mean variation between the two points, but could not find anything.

Given the dramatic variation between people...

In my case, there was 300 point to difference. I pulled blood eod for two weeks as part of a research study and was astonished. Adopted daily injections to compensate.

 

[James]

The numbers would vary greatly based on all the reasons above. The same guy can inject the same amount at the same time and pull blood at the same time each week and that guy will likely get noticeably different results when compared to his previous labs. On a once weekly injections schedule, peak/trough are easier to come by. Is there a consensus of opinion on when exactly is a guys peak and when is his trough if injecting every 3.5 days? Half life & SHBG probably play into that too.

 

[new_man]

Given the dramatic variation between people...

In my case, there was 300 point to difference. I pulled blood eod for two weeks as part of a research study and was astonished. Adopted daily injections to compensate.

How did you get to be part of this research study? Through doctor or connections?
How was the E?D?
If the highest testosterone value is reached after 24-48 hours, then a 300 point difference would be alooot with E3.5D but not on E14D of course! Did you do it SQ or IM?

 

[Vince Carter]

Given the dramatic variation between people...

In my case, there was 300 point to difference. I pulled blood eod for two weeks as part of a research study and was astonished. Adopted daily injections to compensate.

That's the way I did it, bought my own labs over a period of time and saw what was happening and gained a lot of knowledge.

 

[Vince Carter]

The numbers would vary greatly based on all the reasons above. The same guy can inject the same amount at the same time and pull blood at the same time each week and that guy will likely get noticeably different results when compared to his previous labs. On a once weekly injections schedule, peak/trough are easier to come by. Is there a consensus of opinion on when exactly is a guys peak and when is his trough if injecting every 3.5 days? Half life & SHBG probably play into that too.

I don't think that you can extrapolate any data on this topic, nothing you could live by anyway. You would need to buy your own tests at set intervals to get a clear picture...far too many variables in the individual sense to draw any conclusions.

 

[CoastWatcher]

How did you get to be part of this research study? Through doctor or connections?
How was the E?D?
If the highest testosterone value is reached after 24-48 hours, then a 300 point difference would be alooot with E3.5D but not on E14D of course! Did you do it SQ or IM?

My doctor wanted to write a paper advocating smaller, frequent injections based on clinical observation. i participated. On an every 3.5 day injection schedule my low SHBG sent my total testosterone on a roller-coaster ride. We discussed daily injections, and haven't looked back.

Inhad significant ED prior to TRT. In and of itself, TRT improved - but did not resolve - those issues. Daily injections, daily Cialis, and a modified version of Gene's NO stack have made an enormous difference in that area.

I don't focus too terribly much on IM/SQ issues. I essentially do a very shallow IM, moving my injection site about.

 

[CoastWatcher]

That's the way I did it, bought my own labs over a period of time and saw what was happening and gained a lot of knowledge.

If one can, this is the ideal way to manage your protocol. So much to be gained from frequent testing over time.

 

[James]

You would need to buy your own tests at set intervals to get a clear picture.

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And this is peobably less expensive than a lot of guys think it is.

 

[CoastWatcher]

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And this is peobably less expensive than a lot of guys think it is.

Absolutely true. A worthwhile investment in your health.

 

[Vince Carter]

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And this is peobably less expensive than a lot of guys think it is.

Discountedlabs for sure, but with Defy they give me a script for anything I ask ($0), and my private insurance picks up the total tab, no co-pay, no deductible so I can get all the labs I can use for just about zero cost (besides the monthly premiums), which was a huge motivator when I switched to Dr Saya.

 

[Lancealot]

For those in the know, or who have measured both their peak and trough while on test cypionate, what is the general variation between the peak and trough blood levels on an every 3.5 day injection protocol? I gather that the peak and trough difference will be more evened or smoothed out on an every 3.5 day protocol versus a once a week one. I know that everyone is different and that each individual will vary. But in general, let's say that on trough day the testosterone level was 831. Would the peak be in the 1200 range or closer to 1000? I'm just trying to gain an understanding of generally what everyone's experience has been on what the testosterone range is from lowest to highest on an every 3.5 day protocol. Thanks

I'm on a 3.5 day schedule tue am and fri pm 50mg tcyp and mine test over 1500 till the day of injection (trough) its usually around 900(ish). My shbg runs middle to high on the scale.

 

[James]

I'm on a 3.5 day schedule too. 60 mg twice weekly. Right before the next injection, I'm at 780 ng/dl. My shbg is low end of normal.