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Regarding oral testosterone if you are referring to methyltestosterone than YES as it is c17 alpha-alkylated which increases its bio availability and prevents it from being broken down during the first pass through your liver but at the cost of being liver toxic

If you are referring to ANDRIOL-testosterone undecanoate which is only available in CANADA than NO as it is designed to be absorbed through the lymphatic system thus bypassing the destructive first pass through the liver.

It is the METHYLATION of oral testosterone which makes it liver toxic................DHEA/PREGNOLONE are not methylated.

[QUOTE="madman, post: 49656, member: 13851"] Regarding oral testosterone if you are referring to methyltestosterone than YES as it is c17 alpha-alkylated which increases its bio availability and prevents it from being broken down during the first pass through your liver but at the cost of being liver toxic If you are referring to ANDRIOL-testosterone undecanoate which is only available in CANADA than NO as it is designed to be absorbed through the lymphatic system thus bypassing the destructive first pass through the liver. It is the METHYLATION of oral testosterone which makes it liver toxic................DHEA/PREGNOLONE are not methylated. [/QUOTE]

Verification

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038