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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
oral DHEA causes depression
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<blockquote data-quote="lowe2sucks" data-source="post: 66787" data-attributes="member: 13891"><p>In addition to its affinity for the androgen receptor, DHEA has also been found to bind to and activate the <a href="https://en.wikipedia.org/wiki/Estrogen_receptor_alpha" target="_blank">ER&#945;</a> and <a href="https://en.wikipedia.org/wiki/Estrogen_receptor_beta" target="_blank">ER&#946;</a><a href="https://en.wikipedia.org/wiki/Estrogen_receptor" target="_blank">estrogen receptors</a> with K[SUB]i[/SUB] values of 1.1 &#956;M and 0.5 &#956;M, respectively, and <a href="https://en.wikipedia.org/wiki/EC50" target="_blank">EC[SUB]50[/SUB]</a> values of >1 &#956;M and 200 nM, respectively. Though it was found to be a partial agonist of the ER&#945; with a maximal efficacy of 30&#8211;70%, the concentrations required for this degree of activation make it unlikely that the activity of DHEA at this receptor is physiologically meaningful. Remarkably however, DHEA acts as a full agonist of the ER&#946; with a maximal response similar to or actually slightly greater than that of <a href="https://en.wikipedia.org/wiki/Estradiol" target="_blank">estradiol</a>, and its levels in circulation and local tissues in the human body are high enough to activate the receptor to the same degree as that seen with circulating estradiol levels at somewhat higher than their maximal, non-<a href="https://en.wikipedia.org/wiki/Ovulation" target="_blank">ovulatory</a> concentrations; indeed, when combined with estradiol with both at levels equivalent to those of their physiological concentrations, overall activation of the ER&#946; was doubled. As such, it has been proposed that DHEA may be an important and potentially major endogenous <a href="https://en.wikipedia.org/wiki/Estrogen" target="_blank">estrogen</a> in the body.[SUP]<a href="https://en.wikipedia.org/wiki/Dehydroepiandrosterone#cite_note-pmid16684650-10" target="_blank">[10]</a>[/SUP][SUP]<a href="https://en.wikipedia.org/wiki/Dehydroepiandrosterone#cite_note-pmid15994348-35" target="_blank">[35]</a></p><p><span style="font-size: 15px">Source: </span>[/SUP]https://en.wikipedia.org/wiki/Dehydroepiandrosterone</p><p></p><p>So basically DHEA also activated estrogen receptor beta with response similar or slightly greater then estradiol thats why some folks report high e2 symptoms even without that big of an e2 increase on labs.. since it agonizes estrogen receptor beta</p></blockquote><p></p>
[QUOTE="lowe2sucks, post: 66787, member: 13891"] [FONT=sans-serif]In addition to its affinity for the androgen receptor, DHEA has also been found to bind to and activate the [/FONT][URL="https://en.wikipedia.org/wiki/Estrogen_receptor_alpha"]ERα[/URL][FONT=sans-serif] and [/FONT][URL="https://en.wikipedia.org/wiki/Estrogen_receptor_beta"]ERβ[/URL][URL="https://en.wikipedia.org/wiki/Estrogen_receptor"]estrogen receptors[/URL][FONT=sans-serif] with K[/FONT][SUB]i[/SUB][FONT=sans-serif] values of 1.1 μM and 0.5 μM, respectively, and [/FONT][URL="https://en.wikipedia.org/wiki/EC50"]EC[SUB]50[/SUB][/URL][FONT=sans-serif] values of >1 μM and 200 nM, respectively. Though it was found to be a partial agonist of the ERα with a maximal efficacy of 30–70%, the concentrations required for this degree of activation make it unlikely that the activity of DHEA at this receptor is physiologically meaningful. Remarkably however, DHEA acts as a full agonist of the ERβ with a maximal response similar to or actually slightly greater than that of [/FONT][URL="https://en.wikipedia.org/wiki/Estradiol"]estradiol[/URL][FONT=sans-serif], and its levels in circulation and local tissues in the human body are high enough to activate the receptor to the same degree as that seen with circulating estradiol levels at somewhat higher than their maximal, non-[/FONT][URL="https://en.wikipedia.org/wiki/Ovulation"]ovulatory[/URL][FONT=sans-serif] concentrations; indeed, when combined with estradiol with both at levels equivalent to those of their physiological concentrations, overall activation of the ERβ was doubled. As such, it has been proposed that DHEA may be an important and potentially major endogenous [/FONT][URL="https://en.wikipedia.org/wiki/Estrogen"]estrogen[/URL][FONT=sans-serif] in the body.[/FONT][SUP][URL="https://en.wikipedia.org/wiki/Dehydroepiandrosterone#cite_note-pmid16684650-10"][10][/URL][/SUP][SUP][URL="https://en.wikipedia.org/wiki/Dehydroepiandrosterone#cite_note-pmid15994348-35"][35][/URL] [SIZE=4]Source: [/SIZE][/SUP]https://en.wikipedia.org/wiki/Dehydroepiandrosterone So basically DHEA also activated estrogen receptor beta with response similar or slightly greater then estradiol thats why some folks report high e2 symptoms even without that big of an e2 increase on labs.. since it agonizes estrogen receptor beta [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
oral DHEA causes depression
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