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General Peptide Use & Information
Oral BPC-157 For Potential Gut Health
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<blockquote data-quote="BadassBlues" data-source="post: 272189" data-attributes="member: 38526"><p>[URL unfurl="true"]https://examine.com/supplements/bpc-157/research/#yQZ5O2O-peripheral-organ-systems_yQZ5O2O-stomach[/URL]</p><p></p><p></p><p><em>Peripheral Organ Systems</em></p><p><em></em></p><p><em>6.1</em></p><p><em>Stomach</em></p><p><em>The protective effects of BPC-157 on ulcers has been found to be prevented in rats by coadministration of haloperidol (Alpha-1A and Dopamine receptor antagonist), phentolamine (Alpha adrenergic antagonist, nonselective), and clonidine (Alpha-2A adrenergic antagonist, similar to <a href="https://examine.com/supplements/agmatine/" target="_blank">agmatine</a>) but was not affected by prazosin, domperidone, or <a href="https://examine.com/supplements/yohimbine/" target="_blank">yohimbine</a>.<a href="https://examine.com/supplements/bpc-157/research/#ref-23" target="_blank">[23]</a></em></p><p></p><p><em>BPC-157 has shown protective effects against various agents that induce stomach ulcerations, such as cyclophosphamide<a href="https://examine.com/supplements/bpc-157/research/#ref-24" target="_blank">[24]</a> and haloperidol.<a href="https://examine.com/supplements/bpc-157/research/#ref-25" target="_blank">[25]</a></em></p><p><em>6.2</em></p><p><em>Intestines</em></p><p><em>When it comes to inflammation, BPC-157 has shown benefit in rats against the toxins trinitrobenzene sulfonic acid (TNBS)<a href="https://examine.com/supplements/bpc-157/research/#ref-6" target="_blank">[6]</a> and cysteamine,<a href="https://examine.com/supplements/bpc-157/research/#ref-26" target="_blank">[26]</a><a href="https://examine.com/supplements/bpc-157/research/#ref-27" target="_blank">[27]</a><a href="https://examine.com/supplements/bpc-157/research/#ref-15" target="_blank">[15]</a> where both biomarkers of inflammation and visual markers of damage were reduced when BPC-157 was administered alongside the toxins. BPC-157 is not unique in this regard, as other active controls like ranitidine and omeprazole have shown efficacy in the same model of intestinal inflammation,<a href="https://examine.com/supplements/bpc-157/research/#ref-27" target="_blank">[27]</a> though it was mentioned in a review by the authors<a href="https://examine.com/supplements/bpc-157/research/#ref-28" target="_blank">[28]</a> that BPC-157 may be more practical due to proven benefits in other complications of intestinal disease: anastomosis healing, short bowel syndrome, and fistulas.</em></p><p><em>An anastomosis is a connection between two things that are not normally connected, with a fistula being an abnormal type commonly seen during intestinal diseases. Numerous studies have shown BPC-157 injections in rats having a mending property on anastomosis in numerous body regions, including aortic<a href="https://examine.com/supplements/bpc-157/research/#ref-29" target="_blank">[29]</a> and esophagogastic.<a href="https://examine.com/supplements/bpc-157/research/#ref-30" target="_blank">[30]</a> In studies assessing the intestines, benefits have been shown to colovesical,<a href="https://examine.com/supplements/bpc-157/research/#ref-31" target="_blank">[31]</a> rectovaginal,<a href="https://examine.com/supplements/bpc-157/research/#ref-32" target="_blank">[32]</a> colon-colon,<a href="https://examine.com/supplements/bpc-157/research/#ref-15" target="_blank">[15]</a> and ileoileal<a href="https://examine.com/supplements/bpc-157/research/#ref-33" target="_blank">[33]</a> fistulas. This particular benefit may be related to nitric oxide signaling (potentially the VEGFR2-Akt-eNOS pathway BPC-157 influences<a href="https://examine.com/supplements/bpc-157/research/#ref-7" target="_blank">[7]</a>) since L-NAME, a nitric oxide synthase inhibitor, worsens anastomosis healing in a manner ameliorated by BPC-157.<a href="https://examine.com/supplements/bpc-157/research/#ref-30" target="_blank">[30]</a></em></p><p><em>Studies assessing BPC-157 in experimental models of short bowel syndrome also find benefit, with injections of BPC-157 ameliorating this state<a href="https://examine.com/supplements/bpc-157/research/#ref-34" target="_blank">[34]</a><a href="https://examine.com/supplements/bpc-157/research/#ref-35" target="_blank">[35]</a> even when the state is worsened with the addition of L-NAME and diclofenac.<a href="https://examine.com/supplements/bpc-157/research/#ref-35" target="_blank">[35]</a></em></p><p></p><p><em>Most notably, a benefit for anastomosis healing (esophagogastric) has been found in rats given BPC-157 in drinking water (approximately 10 ng/kg or 10 μg/kg daily) without an injection, with no significant difference in efficacy between the two doses and statistically similar efficacy to injections of 10 ng/kg and 10 μg/kg.<a href="https://examine.com/supplements/bpc-157/research/#ref-30" target="_blank">[30]</a></em></p></blockquote><p></p>
[QUOTE="BadassBlues, post: 272189, member: 38526"] [URL unfurl="true"]https://examine.com/supplements/bpc-157/research/#yQZ5O2O-peripheral-organ-systems_yQZ5O2O-stomach[/URL] [I]Peripheral Organ Systems 6.1 Stomach The protective effects of BPC-157 on ulcers has been found to be prevented in rats by coadministration of haloperidol (Alpha-1A and Dopamine receptor antagonist), phentolamine (Alpha adrenergic antagonist, nonselective), and clonidine (Alpha-2A adrenergic antagonist, similar to [URL='https://examine.com/supplements/agmatine/']agmatine[/URL]) but was not affected by prazosin, domperidone, or [URL='https://examine.com/supplements/yohimbine/']yohimbine[/URL].[URL='https://examine.com/supplements/bpc-157/research/#ref-23'][23][/URL][/I] [I]BPC-157 has shown protective effects against various agents that induce stomach ulcerations, such as cyclophosphamide[URL='https://examine.com/supplements/bpc-157/research/#ref-24'][24][/URL] and haloperidol.[URL='https://examine.com/supplements/bpc-157/research/#ref-25'][25][/URL] 6.2 Intestines When it comes to inflammation, BPC-157 has shown benefit in rats against the toxins trinitrobenzene sulfonic acid (TNBS)[URL='https://examine.com/supplements/bpc-157/research/#ref-6'][6][/URL] and cysteamine,[URL='https://examine.com/supplements/bpc-157/research/#ref-26'][26][/URL][URL='https://examine.com/supplements/bpc-157/research/#ref-27'][27][/URL][URL='https://examine.com/supplements/bpc-157/research/#ref-15'][15][/URL] where both biomarkers of inflammation and visual markers of damage were reduced when BPC-157 was administered alongside the toxins. BPC-157 is not unique in this regard, as other active controls like ranitidine and omeprazole have shown efficacy in the same model of intestinal inflammation,[URL='https://examine.com/supplements/bpc-157/research/#ref-27'][27][/URL] though it was mentioned in a review by the authors[URL='https://examine.com/supplements/bpc-157/research/#ref-28'][28][/URL] that BPC-157 may be more practical due to proven benefits in other complications of intestinal disease: anastomosis healing, short bowel syndrome, and fistulas. An anastomosis is a connection between two things that are not normally connected, with a fistula being an abnormal type commonly seen during intestinal diseases. Numerous studies have shown BPC-157 injections in rats having a mending property on anastomosis in numerous body regions, including aortic[URL='https://examine.com/supplements/bpc-157/research/#ref-29'][29][/URL] and esophagogastic.[URL='https://examine.com/supplements/bpc-157/research/#ref-30'][30][/URL] In studies assessing the intestines, benefits have been shown to colovesical,[URL='https://examine.com/supplements/bpc-157/research/#ref-31'][31][/URL] rectovaginal,[URL='https://examine.com/supplements/bpc-157/research/#ref-32'][32][/URL] colon-colon,[URL='https://examine.com/supplements/bpc-157/research/#ref-15'][15][/URL] and ileoileal[URL='https://examine.com/supplements/bpc-157/research/#ref-33'][33][/URL] fistulas. This particular benefit may be related to nitric oxide signaling (potentially the VEGFR2-Akt-eNOS pathway BPC-157 influences[URL='https://examine.com/supplements/bpc-157/research/#ref-7'][7][/URL]) since L-NAME, a nitric oxide synthase inhibitor, worsens anastomosis healing in a manner ameliorated by BPC-157.[URL='https://examine.com/supplements/bpc-157/research/#ref-30'][30][/URL] Studies assessing BPC-157 in experimental models of short bowel syndrome also find benefit, with injections of BPC-157 ameliorating this state[URL='https://examine.com/supplements/bpc-157/research/#ref-34'][34][/URL][URL='https://examine.com/supplements/bpc-157/research/#ref-35'][35][/URL] even when the state is worsened with the addition of L-NAME and diclofenac.[URL='https://examine.com/supplements/bpc-157/research/#ref-35'][35][/URL][/I] [I]Most notably, a benefit for anastomosis healing (esophagogastric) has been found in rats given BPC-157 in drinking water (approximately 10 ng/kg or 10 μg/kg daily) without an injection, with no significant difference in efficacy between the two doses and statistically similar efficacy to injections of 10 ng/kg and 10 μg/kg.[URL='https://examine.com/supplements/bpc-157/research/#ref-30'][30][/URL][/I] [/QUOTE]
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Oral BPC-157 For Potential Gut Health
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