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Oral BPC-157 For Potential Gut Health
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<blockquote data-quote="BadassBlues" data-source="post: 271768" data-attributes="member: 38526"><p>This post is focused on the <em><strong>oral</strong></em> route for BPC 157 and the<em> possibilities</em> it may have for digestive ailments and overall gut health.</p><p></p><p>The studies posted are there for reference and educational purposes. There are many questions to be answered before any kind of determination can be made as to the application of the oral use of BPC 157.</p><p></p><p>A brief history of the peptide is in order. BPC 157 is a <em>naturally occurring compound</em> that we all have in our gastric juices. The synthetic version consists of 15 amino acids.</p><p>[ATTACH=full]40126[/ATTACH]</p><p> BPC is an acronym for Body Protection Compound. The theory is that by adding additional amounts of this <em>naturally occurring compound </em>to our endogenous production, we can enhance the healing and regenerative effects. BPC was discovered years ago by researchers looking at the healing benefits of gastric juices. The studies presented, along with anecdotal evidence would indicate a strong possibility that this is true in certain cases. There have been no human trials as yet, but a lot of anecdotal evidence with a predictable range of variables is easily found by searching the subject.</p><p></p><p>Theoretically speaking, it would make sense that amplifying the regenerative and reparative effects of the healing properties of our natural gastric juices could be a good thing for certain people in certain situations. Also speaking theoretically, some people would likely not see any benefit from it. Simply put, "If it aint broke, don't fix it" might apply here.</p><p></p><p>BPC 157 has a notable effect on neurotransmitters, which is completely understandable as neurotransmitters are directly involved in the digestive process.</p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/[/URL]</p><p></p><p><em>Most NTs, including dopamine (DA), gamma-aminobutyric acid (GABA), serotonin, and endocannabinoids, are synthesized within the gut and in the brain. <strong>About 95 % of the body’s serotonin comes from the gut, where it behaves both as a paracrine messenger and as a NT [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/#B5-molecules-28-00210" target="_blank">5</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/#B6-molecules-28-00210" target="_blank">6</a>].</strong> NTs are major functional molecules in the immune system, signaling the occurrence of certain actions [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/#B7-molecules-28-00210" target="_blank">7</a>]. The functions of some major NTs are shown in <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/figure/molecules-28-00210-f002/" target="_blank">Figure 2</a>. Studies have highlighted a possible linkage between NT dysfunction and many neurological and psychiatric disorders such as Parkinson’s disease, Alzheimer’s disease [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/#B8-molecules-28-00210" target="_blank">8</a>], depression, schizophrenia, borderline personality disorder [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/#B9-molecules-28-00210" target="_blank">9</a>], and fibromyalgia [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/#B10-molecules-28-00210" target="_blank">10</a>].</em></p><p><em></em></p><p><em>(A quick shoutout to [USER=44064]@FunkOdyssey[/USER] in relation to the anhedonia experienced while taking BPC 157)</em></p><p></p><p>It would be easy to see why certain subsets of people may have widely differing experiences with this compound.</p><p></p><p>There is a lot to unpack and discover here. My immediate questions regarding the oral administration are:</p><p></p><p>1. Considering this is a derivative of the gastric juices, is it still subject to degradation in the stomach by stomach acids?</p><p></p><p>2. If the stomach in particular is the target, should the capsules be enteric coated?</p><p></p><p>3. Is it still as effective for digestive health if it does bypass the stomach (enteric coating) and is absorbed in the intestinal tract?</p><p></p><p>4. Possibility of a 2 layer delivery system, 1 for the stomach and 1 for the intestinal tract?</p><p></p><p>I do believe this merits further investigation. I can see it as a potential benefit for certain situations.</p><p></p><p>All thoughts and ideas are welcome.</p></blockquote><p></p>
[QUOTE="BadassBlues, post: 271768, member: 38526"] This post is focused on the [I][B]oral[/B][/I] route for BPC 157 and the[I] possibilities[/I] it may have for digestive ailments and overall gut health. The studies posted are there for reference and educational purposes. There are many questions to be answered before any kind of determination can be made as to the application of the oral use of BPC 157. A brief history of the peptide is in order. BPC 157 is a [I]naturally occurring compound[/I] that we all have in our gastric juices. The synthetic version consists of 15 amino acids. [ATTACH type="full"]40126[/ATTACH] BPC is an acronym for Body Protection Compound. The theory is that by adding additional amounts of this [I]naturally occurring compound [/I]to our endogenous production, we can enhance the healing and regenerative effects. BPC was discovered years ago by researchers looking at the healing benefits of gastric juices. The studies presented, along with anecdotal evidence would indicate a strong possibility that this is true in certain cases. There have been no human trials as yet, but a lot of anecdotal evidence with a predictable range of variables is easily found by searching the subject. Theoretically speaking, it would make sense that amplifying the regenerative and reparative effects of the healing properties of our natural gastric juices could be a good thing for certain people in certain situations. Also speaking theoretically, some people would likely not see any benefit from it. Simply put, "If it aint broke, don't fix it" might apply here. BPC 157 has a notable effect on neurotransmitters, which is completely understandable as neurotransmitters are directly involved in the digestive process. [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/[/URL] [I]Most NTs, including dopamine (DA), gamma-aminobutyric acid (GABA), serotonin, and endocannabinoids, are synthesized within the gut and in the brain. [B]About 95 % of the body’s serotonin comes from the gut, where it behaves both as a paracrine messenger and as a NT [[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/#B5-molecules-28-00210']5[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/#B6-molecules-28-00210']6[/URL]].[/B] NTs are major functional molecules in the immune system, signaling the occurrence of certain actions [[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/#B7-molecules-28-00210']7[/URL]]. The functions of some major NTs are shown in [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/figure/molecules-28-00210-f002/']Figure 2[/URL]. Studies have highlighted a possible linkage between NT dysfunction and many neurological and psychiatric disorders such as Parkinson’s disease, Alzheimer’s disease [[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/#B8-molecules-28-00210']8[/URL]], depression, schizophrenia, borderline personality disorder [[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/#B9-molecules-28-00210']9[/URL]], and fibromyalgia [[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822089/#B10-molecules-28-00210']10[/URL]]. (A quick shoutout to [USER=44064]@FunkOdyssey[/USER] in relation to the anhedonia experienced while taking BPC 157)[/I] It would be easy to see why certain subsets of people may have widely differing experiences with this compound. There is a lot to unpack and discover here. My immediate questions regarding the oral administration are: 1. Considering this is a derivative of the gastric juices, is it still subject to degradation in the stomach by stomach acids? 2. If the stomach in particular is the target, should the capsules be enteric coated? 3. Is it still as effective for digestive health if it does bypass the stomach (enteric coating) and is absorbed in the intestinal tract? 4. Possibility of a 2 layer delivery system, 1 for the stomach and 1 for the intestinal tract? I do believe this merits further investigation. I can see it as a potential benefit for certain situations. All thoughts and ideas are welcome. [/QUOTE]
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Oral BPC-157 For Potential Gut Health
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