Optum Rx removes reauthorizations from an additional 40 drugs including Testosterone and knee osteoarthritis injectables

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Beginning in January 2026, Optum Rx is removing reauthorizations for two new drug classes: hormone therapies and knee osteoarthritis injectables.

Beginning Jan. 1, 2026, Optum Rx, the pharmacy benefit manager of UnitedHealthcare, will reduce reauthorizations for an additional 40 drugs. This expands on the PBM’s efforts earlier this year, and there are now 180 medications with reduced reauthorization requirements.

This effort builds on United Healthcare’s commitment made in March 2025 to make prescription drugs more accessible. In today’s announcement, Optum Rx is eliminating reauthorization on hormone therapies and those for knee authorization.



The additional drug that no longer need reauthorization include:

  • Hormone Therapy: Aveed inj, Azmiro inj, Depo-Testosterone inj, Testosterone cypionate inj, Testone inj, Testopel implant pellets, Testosterone implant pellets, Testosterone enanthate inj, Xyosted inj, Jatenzo capsules, Kyzatrex capsules, Methitest tablets, Methyltestosterone capsules, Tlando capsules, Androgel, Natesto, Fortesta gel, Testim gel, Vogelxo gel, Testosterone gel, Testosterone solution
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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